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10.1038/s41598-017-00080-4

http://scihub22266oqcxt.onion/10.1038/s41598-017-00080-4
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suck abstract from ncbi


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pmid28232731      Sci+Rep 2017 ; 7 (ä): ä
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  • Roles of Serum Calcium, Phosphorus, PTH and ALP on Mortality in Peritoneal Dialysis Patients: A Nationwide, Population-based Longitudinal Study Using TWRDS 2005?2012 #MMPMID28232731
  • Liu CT; Lin YC; Lin YC; Kao CC; Chen HH; Hsu CC; Wu MS
  • Sci Rep 2017[]; 7 (ä): ä PMID28232731show ga
  • Biomarkers of chronic kidney disease-mineral and bone disorder (CKD-MBD) correlate with morbidity and mortality in dialysis patients. However, the comparative roles of each CKD-MBD biomarker remained undetermined on long-term peritoneal dialysis (PD) patients. This retrospective study, employing a population-based database, aimed to evaluate the performance and provide the best evidence of each biomarker of CKD-MBD as predictor of all-cause mortality. Throughout the 8-year study period, total 12,116 PD patients were included in this study. Cox proportional regression and Kaplan-Meier method were used for survival analysis. For Cox regression model, baseline measurements and time-varying covariates were used for analysis. In Cox regression model using time-dependent covariates, serum calcium level of ?9.5?mg/dL was associated with increased mortality. For phosphorus, serum levels of either ?6.5?mg/dL or <3.5?mg/dL were associated with increased mortality. For parathyroid hormone (PTH), higher serum levels were not associated increased mortality. For alkaline phosphatase (ALP), mortality increased at levels ?100?IU/L. Our findings suggested that the detrimental effect of ALP on survival was more consistent, while serum calcium, phosphorus and PTH may have a less prominent effect on mortality. This study provided additional information for manipulating CKD-MBD biomarkers in PD patients.
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