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2017 ; 7
(1
): 33
Nephropedia Template TP
gab.com Text
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English Wikipedia
Roles of Serum Calcium, Phosphorus, PTH and ALP on Mortality in Peritoneal
Dialysis Patients: A Nationwide, Population-based Longitudinal Study Using TWRDS
2005-2012
#MMPMID28232731
Liu CT
; Lin YC
; Lin YC
; Kao CC
; Chen HH
; Hsu CC
; Wu MS
Sci Rep
2017[Feb]; 7
(1
): 33
PMID28232731
show ga
Biomarkers of chronic kidney disease-mineral and bone disorder (CKD-MBD)
correlate with morbidity and mortality in dialysis patients. However, the
comparative roles of each CKD-MBD biomarker remained undetermined on long-term
peritoneal dialysis (PD) patients. This retrospective study, employing a
population-based database, aimed to evaluate the performance and provide the best
evidence of each biomarker of CKD-MBD as predictor of all-cause mortality.
Throughout the 8-year study period, total 12,116 PD patients were included in
this study. Cox proportional regression and Kaplan-Meier method were used for
survival analysis. For Cox regression model, baseline measurements and
time-varying covariates were used for analysis. In Cox regression model using
time-dependent covariates, serum calcium level of ?9.5?mg/dL was associated with
increased mortality. For phosphorus, serum levels of either ?6.5?mg/dL or
<3.5?mg/dL were associated with increased mortality. For parathyroid hormone
(PTH), higher serum levels were not associated increased mortality. For alkaline
phosphatase (ALP), mortality increased at levels ?100?IU/L. Our findings
suggested that the detrimental effect of ALP on survival was more consistent,
while serum calcium, phosphorus and PTH may have a less prominent effect on
mortality. This study provided additional information for manipulating CKD-MBD
biomarkers in PD patients.
|Adult
[MESH]
|Aged
[MESH]
|Alkaline Phosphatase/blood
[MESH]
|Biomarkers/*blood
[MESH]
|Calcium/blood
[MESH]
|Chronic Kidney Disease-Mineral and Bone Disorder/metabolism/*mortality
[MESH]