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10.1038/s41598-017-00079-x http://scihub22266oqcxt.onion/10.1038/s41598-017-00079-x C5428321!5428321!28246385     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28246385|t=2017. ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression |pdf=|usr=}}{{28246385}} gab.com Text ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28246385 #FOAvip Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mesenchymal transition (EMT), a critical cellular event for metastasis of malignant tumors of epithelium origin. ZEB1 is also expressed in UM and high expression of ZEB1 correlates with UM advancement, but has little effect on cell morphology. We show that spindle UM cells can become epithelioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dedifferentiation, proliferation, invasiveness, and dissemination. We provide evidence that ZEB1 binds not only to repress critical genes involving in pigment synthesis, mitosis, adherent junctions, but also to transactivate genes involving in matrix degradation and cellular locomotion to propel UM progression towards metastasis. We conclude that ZEB1 is a major oncogenic factor required for UM progression and could be a potential therapeutic target for treating UM in the clinic. Twit Text FOAVip ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28246385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28246385 #FOAvip English Wikipedia <ref>{{Cite pmid|28246385}}</ref> ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression #MMPMID28246385 Chen Y; Lu X; Montoya-Durango DE; Liu YH; Dean KC; Darling DS; Kaplan HJ; Dean DC; Gao L; Liu Y Sci Rep 2017[]; 7 (ä): ä PMID28246385show ga Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mesenchymal transition (EMT), a critical cellular event for metastasis of malignant tumors of epithelium origin. ZEB1 is also expressed in UM and high expression of ZEB1 correlates with UM advancement, but has little effect on cell morphology. We show that spindle UM cells can become epithelioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dedifferentiation, proliferation, invasiveness, and dissemination. We provide evidence that ZEB1 binds not only to repress critical genes involving in pigment synthesis, mitosis, adherent junctions, but also to transactivate genes involving in matrix degradation and cellular locomotion to propel UM progression towards metastasis. We conclude that ZEB1 is a major oncogenic factor required for UM progression and could be a potential therapeutic target for treating UM in the clinic. äZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanom(epmc).pdf DeepDyve Pubget Overpricing