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10.1007/s13205-017-0713-x http://scihub22266oqcxt.onion/10.1007/s13205-017-0713-x C5428098!5428098!28444588     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       3+Biotech 2017 ; 7 (1): ä Nephropedia Template TP {{tp|p=28444588|t=2017. Unveiling differentially expressed genes upon regulation of transcription factors in sepsis |pdf=|usr=}}{{28444588}} gab.com Text Unveiling differentially expressed genes upon regulation of transcription factors in sepsis JO: 3 Biotech http://www.kidney.de/pget.php?&tw=1&pmid=28444588 #FOAvip In this study, we integrated the gene expression data of sepsis to reveal more precise genome-wide expression signature to shed light on the pathological mechanism of sepsis. Differentially expressed genes via integrating five microarray datasets from the Gene Expression Omnibus database were obtained. The gene function and involved pathways of differentially expressed genes (DEGs) were detected by GeneCodis3. Transcription factors (TFs) targeting top 20 dysregulated DEGs (including up- and downregulated genes) were found based on the TRANSFAC. A total of 1339 DEGs were detected including 788 upregulated and 551 downregulated genes. These genes were mostly involved in DNA-dependent transcription regulation, blood coagulation, and innate immune response, pathogenic escherichia coli infection, epithelial cell signaling in helicobacter pylori infection, and chemokine signaling pathway. TFs bioinformatic analysis of 20 DEGs generated 374 pairs of TF-target gene involving 47 TFs. At last, we found that five top ten upregulated DEGs (S100A8, S100A9, S100A12, PGLYRP1 and MMP9) and three downregulated DEGs (ZNF84, CYB561A3 and BST1) were under the regulation of three hub TFs of Pax-4, POU2F1, and Nkx2?5. The identified eight DEGs may be regarded as the diagnosis marker and drug target for sepsis.Electronic supplementary material: The online version of this article (doi:10.1007/s13205-017-0713-x) contains supplementary material, which is available to authorized users. Twit Text FOAVip Unveiling differentially expressed genes upon regulation of transcription factors in sepsis ????3 Biotech http://www.kidney.de/pget.php?&tw=1&pmid=28444588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28444588 #FOAvip English Wikipedia <ref>{{Cite pmid|28444588}}</ref> Unveiling differentially expressed genes upon regulation of transcription factors in sepsis #MMPMID28444588 Zhang J; Cheng Y; Duan M; Qi N; Liu J 3 Biotech 2017[May]; 7 (1): ä PMID28444588show ga In this study, we integrated the gene expression data of sepsis to reveal more precise genome-wide expression signature to shed light on the pathological mechanism of sepsis. Differentially expressed genes via integrating five microarray datasets from the Gene Expression Omnibus database were obtained. The gene function and involved pathways of differentially expressed genes (DEGs) were detected by GeneCodis3. Transcription factors (TFs) targeting top 20 dysregulated DEGs (including up- and downregulated genes) were found based on the TRANSFAC. A total of 1339 DEGs were detected including 788 upregulated and 551 downregulated genes. These genes were mostly involved in DNA-dependent transcription regulation, blood coagulation, and innate immune response, pathogenic escherichia coli infection, epithelial cell signaling in helicobacter pylori infection, and chemokine signaling pathway. TFs bioinformatic analysis of 20 DEGs generated 374 pairs of TF-target gene involving 47 TFs. At last, we found that five top ten upregulated DEGs (S100A8, S100A9, S100A12, PGLYRP1 and MMP9) and three downregulated DEGs (ZNF84, CYB561A3 and BST1) were under the regulation of three hub TFs of Pax-4, POU2F1, and Nkx2?5. The identified eight DEGs may be regarded as the diagnosis marker and drug target for sepsis.Electronic supplementary material: The online version of this article (doi:10.1007/s13205-017-0713-x) contains supplementary material, which is available to authorized users. äUnveiling differentially expressed genes upon regulation of transcript(epmc).pdf DeepDyve Pubget Overpricing