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10.1038/s41598-017-00282-w http://scihub22266oqcxt.onion/10.1038/s41598-017-00282-w C5427997!5427997 !28336942     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28336942 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 325 Nephropedia Template TP {{tp|p=28336942 |t=2017. Selective inhibitor of Wnt/?-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model |pdf=|usr=}}{{28336942 }} gab.com Text Selective inhibitor of Wnt/ -catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28336942 #FOAvip Chronic hepatitis C virus (HCV) infection is one of the major causes of serious liver diseases, including liver cirrhosis. There are no anti-fibrotic drugs with efficacy against liver cirrhosis. Wnt/?-catenin signaling has been implicated in the pathogenesis of a variety of tissue fibrosis. In the present study, we investigated the effects of a ?-catenin/CBP (cyclic AMP response element binding protein) inhibitor on liver fibrosis. The anti-fibrotic activity of PRI-724, a selective inhibitor of ?-catenin/CBP, was assessed in HCV GT1b transgenic mice at 18 months after HCV genome expression. PRI-724 was injected intraperitoneally or subcutaneously in these mice for 6 weeks. PRI-724 reduced liver fibrosis, which was indicated by silver stain, Sirius Red staining, and hepatic hydroxyproline levels, in HCV mice while attenuating ?SMA induction. PRI-724 led to increased levels of matrix metalloproteinase (MMP)-8 mRNA in the liver, along with elevated levels of intrahepatic neutrophils and macrophages/monocytes. The induced intrahepatic neutrophils and macrophages/monocytes were identified as the source of MMP-8. In conclusion, PRI-724 ameliorated HCV-induced liver fibrosis in mice. We hypothesize that inhibition of hepatic stellate cells activation and induction of fibrolytic cells expressing MMP-8 contribute to the anti-fibrotic effects of PRI-724. PRI-724 is a drug candidate which possesses anti-fibrotic effect. Twit Text FOAVip Selective inhibitor of Wnt/ -catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28336942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28336942 #FOAvip English Wikipedia <ref>{{Cite pmid|28336942 }}</ref> Selective inhibitor of Wnt/?-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model #MMPMID28336942 Tokunaga Y ; Osawa Y ; Ohtsuki T ; Hayashi Y ; Yamaji K ; Yamane D ; Hara M ; Munekata K ; Tsukiyama-Kohara K ; Hishima T ; Kojima S ; Kimura K ; Kohara M Sci Rep 2017[Mar]; 7 (1 ): 325 PMID28336942 show ga Chronic hepatitis C virus (HCV) infection is one of the major causes of serious liver diseases, including liver cirrhosis. There are no anti-fibrotic drugs with efficacy against liver cirrhosis. Wnt/?-catenin signaling has been implicated in the pathogenesis of a variety of tissue fibrosis. In the present study, we investigated the effects of a ?-catenin/CBP (cyclic AMP response element binding protein) inhibitor on liver fibrosis. The anti-fibrotic activity of PRI-724, a selective inhibitor of ?-catenin/CBP, was assessed in HCV GT1b transgenic mice at 18 months after HCV genome expression. PRI-724 was injected intraperitoneally or subcutaneously in these mice for 6 weeks. PRI-724 reduced liver fibrosis, which was indicated by silver stain, Sirius Red staining, and hepatic hydroxyproline levels, in HCV mice while attenuating ?SMA induction. PRI-724 led to increased levels of matrix metalloproteinase (MMP)-8 mRNA in the liver, along with elevated levels of intrahepatic neutrophils and macrophages/monocytes. The induced intrahepatic neutrophils and macrophages/monocytes were identified as the source of MMP-8. In conclusion, PRI-724 ameliorated HCV-induced liver fibrosis in mice. We hypothesize that inhibition of hepatic stellate cells activation and induction of fibrolytic cells expressing MMP-8 contribute to the anti-fibrotic effects of PRI-724. PRI-724 is a drug candidate which possesses anti-fibrotic effect. |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage [MESH] |Cyclic AMP Response Element-Binding Protein/*antagonists & inhibitors [MESH] |Disease Models, Animal [MESH] |Enzyme Inhibitors/*administration & dosage [MESH] |Hepatitis C, Chronic/*complications [MESH] |Histocytochemistry [MESH] |Injections, Intraperitoneal [MESH] |Liver Cirrhosis/*pathology [MESH] |Mice, Transgenic [MESH] |Pyrimidinones/*administration & dosage [MESH] |Treatment Outcome [MESH]Selective inhibitor of Wnt/?-catenin/CBP signaling ameliorates hepatit(epmc).pdf DeepDyve Pubget Overpricing