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10.1038/s41598-017-00139-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-00139-2 C5427844!5427844!28298636     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28298636|t=2017. The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts |pdf=|usr=}}{{28298636}} gab.com Text The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28298636 #FOAvip Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength. Proper bone homeostasis and skeletal strength are maintained by balancing OC function with the bone-forming function of osteoblasts. Unfortunately, current treatments that broadly inhibit OC differentiation or function may also interfere with coupled bone formation. We therefore identified a factor, the purinergic receptor P2X5 that is highly expressed during the OC maturation phase, and which we show here plays no apparent role in early bone development and homeostasis, but which is required for osteoclast-mediated inflammatory bone loss and hyper-multinucleation of OCs. We further demonstrate that P2X5 is required for ATP-mediated inflammasome activation and IL-1? production by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous IL-1?. These findings identify a mechanism by which OCs react to inflammatory stimuli, and may identify purinergic signaling as a therapeutic target for bone loss-related inflammatory conditions. Twit Text FOAVip The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28298636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28298636 #FOAvip English Wikipedia <ref>{{Cite pmid|28298636}}</ref> The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts #MMPMID28298636 Kim H; Walsh MC; Takegahara N; Middleton SA; Shin HI; Kim J; Choi Y Sci Rep 2017[]; 7 (ä): ä PMID28298636show ga Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength. Proper bone homeostasis and skeletal strength are maintained by balancing OC function with the bone-forming function of osteoblasts. Unfortunately, current treatments that broadly inhibit OC differentiation or function may also interfere with coupled bone formation. We therefore identified a factor, the purinergic receptor P2X5 that is highly expressed during the OC maturation phase, and which we show here plays no apparent role in early bone development and homeostasis, but which is required for osteoclast-mediated inflammatory bone loss and hyper-multinucleation of OCs. We further demonstrate that P2X5 is required for ATP-mediated inflammasome activation and IL-1? production by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous IL-1?. These findings identify a mechanism by which OCs react to inflammatory stimuli, and may identify purinergic signaling as a therapeutic target for bone loss-related inflammatory conditions. äThe purinergic receptor P2X5 regulates inflammasome activity and hyper(epmc).pdf DeepDyve Pubget Overpricing