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10.1146/annurev-cellbio-111315-125306 http://scihub22266oqcxt.onion/10.1146/annurev-cellbio-111315-125306 C5427510!5427510!27362646     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Cell+Dev+Biol 2016 ; 32 (ä): 693-711 Nephropedia Template TP {{tp|p=27362646|t=2016. Emergence and Evolution of Secondary Lymphoid Organs |pdf=|usr=}}{{27362646}} gab.com Text Emergence and Evolution of Secondary Lymphoid Organs JO: Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27362646 #FOAvip For effective adaptive immunity to foreign antigens (Ag), secondary lymphoid organs (SLO) provide the confined environment in which Ag-restricted lymphocytes, with very low precursor frequencies, interact with Ag on Ag-presenting cells (APC). The spleen is the primordial SLO, arising in conjunction with adaptive immunity in early jawed vertebrates. The spleen, especially the spleen?s lymphoid compartment, the white pulp (WP), has undergone numerous modifications over evolutionary time. We describe the progressive advancement of splenic WP complexity, which evolved in parallel with the increasing functionality of adaptive immunity. The Ag-presenting function of follicular dendritic cells (FDC) also likely emerged at the inception of adaptive immunity, and we propose that a single type of hematopoietically derived APC displayed Ag to both T and B cells. A dedicated FDC, derived from a vascular precursor, is a recent evolutionary innovation that likely permitted the robust affinity maturation found in mammals. Twit Text FOAVip Emergence and Evolution of Secondary Lymphoid Organs ????Annu Rev Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27362646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27362646 #FOAvip English Wikipedia <ref>{{Cite pmid|27362646}}</ref> Emergence and Evolution of Secondary Lymphoid Organs #MMPMID27362646 Neely HR; Flajnik MF Annu Rev Cell Dev Biol 2016[Oct]; 32 (ä): 693-711 PMID27362646show ga For effective adaptive immunity to foreign antigens (Ag), secondary lymphoid organs (SLO) provide the confined environment in which Ag-restricted lymphocytes, with very low precursor frequencies, interact with Ag on Ag-presenting cells (APC). The spleen is the primordial SLO, arising in conjunction with adaptive immunity in early jawed vertebrates. The spleen, especially the spleen?s lymphoid compartment, the white pulp (WP), has undergone numerous modifications over evolutionary time. We describe the progressive advancement of splenic WP complexity, which evolved in parallel with the increasing functionality of adaptive immunity. The Ag-presenting function of follicular dendritic cells (FDC) also likely emerged at the inception of adaptive immunity, and we propose that a single type of hematopoietically derived APC displayed Ag to both T and B cells. A dedicated FDC, derived from a vascular precursor, is a recent evolutionary innovation that likely permitted the robust affinity maturation found in mammals. äEmergence and Evolution of Secondary Lymphoid Organs (epmc).pdf DeepDyve Pubget Overpricing