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10.1038/nature22322 http://scihub22266oqcxt.onion/10.1038/nature22322 C5427179!5427179!28467822     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 545 (7653): 224-8 Nephropedia Template TP {{tp|p=28467822|t=2017. FGF-dependent metabolic control of vascular development |pdf=|usr=}}{{28467822}} gab.com Text FGF-dependent metabolic control of vascular development JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial cells. Recent studies have suggested that changes in cellular metabolism are of importance to these processes1. While much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism2,3, little is understood about the role of fibroblast growth factors (FGFs) in this context4. Here we identify FGF receptor (FGFR) signaling as a critical regulator of vascular development. This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease in HK2 levels in the absence of FGF signaling inputs results in decreased glycolysis leading to impaired endothelial cell proliferation and migration. Pan-endothelial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/r3 double mutant mice while HK2 overexpression partially rescues the defects caused by suppression of FGF signaling. Thus, FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development. Twit Text FOAVip FGF-dependent metabolic control of vascular development ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28467822 #FOAvip English Wikipedia <ref>{{Cite pmid|28467822}}</ref> FGF-dependent metabolic control of vascular development #MMPMID28467822 Yu P; Wilhelm K; Dubrac A; Tung JK; Alves TC; Fang JS; Xie Y; Zhu J; Chen Z; De Smet F; Zhang J; Jin SW; Sun L; Sun H; Kibbey RG; Hirschi KK; Hay N; Carmeliet P; Chittenden TW; Eichmann A; Potente M; Simons M Nature 2017[May]; 545 (7653): 224-8 PMID28467822show ga Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial cells. Recent studies have suggested that changes in cellular metabolism are of importance to these processes1. While much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism2,3, little is understood about the role of fibroblast growth factors (FGFs) in this context4. Here we identify FGF receptor (FGFR) signaling as a critical regulator of vascular development. This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease in HK2 levels in the absence of FGF signaling inputs results in decreased glycolysis leading to impaired endothelial cell proliferation and migration. Pan-endothelial- and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/r3 double mutant mice while HK2 overexpression partially rescues the defects caused by suppression of FGF signaling. Thus, FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development. äFGF-dependent metabolic control of vascular development (epmc).pdf DeepDyve Pubget Overpricing