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2017 ; 2017
(ä): 7915975
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Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive
Pulmonary Disease: Lessons from Animal Models
#MMPMID28536707
Huang G
; Xu XC
; Zhou JS
; Li ZY
; Chen HP
; Wang Y
; Li W
; Shen HH
; Chen ZH
J Immunol Res
2017[]; 2017
(ä): 7915975
PMID28536707
show ga
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality
worldwide, which is characterized by chronic bronchitis, destruction of small
airways, and enlargement/disorganization of alveoli. It is generally accepted
that the neutrophilic airway inflammation observed in the lungs of COPD patients
is intrinsically linked to the tissue destruction and alveolar airspace
enlargement, leading to disease progression. Animal models play an important role
in studying the underlying mechanisms of COPD as they address questions involving
integrated whole body responses. This review aims to summarize the current animal
models of COPD, focusing on their advantages and disadvantages on immune
responses and neutrophilic inflammation. Also, we propose a potential new animal
model of COPD, which may mimic the most characteristics of human COPD
pathogenesis, including persistent moderate-to-high levels of neutrophilic
inflammation.