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2017 ; 2017
(ä): 6956794
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Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of
Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
#MMPMID28536700
Mellor LF
; Huebner P
; Cai S
; Mohiti-Asli M
; Taylor MA
; Spang J
; Shirwaiker RA
; Loboa EG
Biomed Res Int
2017[]; 2017
(ä): 6956794
PMID28536700
show ga
Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and
fiber diameters that closely resemble the architecture of native extracellular
matrix. However, it generates limited three-dimensional structures of relevant
physiological thicknesses. 3D printing allows digitally controlled fabrication of
three-dimensional single/multimaterial constructs with precisely ordered fiber
and pore architecture in a single build. However, this approach generally lacks
the ability to achieve submicron resolution features to mimic native tissue. The
goal of this study was to fabricate and evaluate 3D printed, electrospun, and
combination of 3D printed/electrospun scaffolds to mimic the native architecture
of heterogeneous tissue. We assessed their ability to support viability and
proliferation of human adipose derived stem cells (hASC). Cells had increased
proliferation and high viability over 21 days on all scaffolds. We further tested
implantation of stacked-electrospun scaffold versus combined electrospun/3D
scaffold on a cadaveric pig knee model and found that stacked-electrospun
scaffold easily delaminated during implantation while the combined scaffold was
easier to implant. Our approach combining these two commonly used scaffold
fabrication technologies allows for the creation of a scaffold with more close
resemblance to heterogeneous tissue architecture, holding great potential for
tissue engineering and regenerative medicine applications of osteochondral tissue
and other heterogeneous tissues.
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