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10.1007/s12551-014-0151-5 http://scihub22266oqcxt.onion/10.1007/s12551-014-0151-5 C5425749!5425749!28509977     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+Rev 2015 ; 7 (1): 5-14 Nephropedia Template TP {{tp|p=28509977|t=2015. The role of super-relaxed myosin in skeletal and cardiac muscle |pdf=|usr=}}{{28509977}} gab.com Text The role of super-relaxed myosin in skeletal and cardiac muscle JO: Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28509977 #FOAvip The super-relaxed (SRX) state of myosin was only recently reported in striated muscle. It is characterised by a sub-population of myosin heads with a highly inhibited rate of ATP turnover. Myosin heads in the SRX state are bound to each other along the thick filament core producing a highly ordered arrangement. Upon activation, these heads project into the interfilament space where they can bind to the actin filaments. Thus far, the population and lifetimes of myosin heads in the SRX state have been characterised in rabbit cardiac, and fast and slow skeletal muscle, as well as in the skeletal muscle of the tarantula. These studies suggest that the role of SRX in cardiac and skeletal muscle regulation is tailored to their specific functions. In skeletal muscle, the SRX modulates the resting metabolic rate. Cardiac SRX represents a ?reserve? of inactive myosin heads that may protect the heart during times of stress, e.g. hypoxia and ischaemia. These heads may also be called up when there is a sustained demand for increased power. The SRX in cardiac muscle provides a potential target for novel therapies. Twit Text FOAVip The role of super-relaxed myosin in skeletal and cardiac muscle ????Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28509977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28509977 #FOAvip English Wikipedia <ref>{{Cite pmid|28509977}}</ref> The role of super-relaxed myosin in skeletal and cardiac muscle #MMPMID28509977 McNamara JW; Li A; dos Remedios CG; Cooke R Biophys Rev 2015[Mar]; 7 (1): 5-14 PMID28509977show ga The super-relaxed (SRX) state of myosin was only recently reported in striated muscle. It is characterised by a sub-population of myosin heads with a highly inhibited rate of ATP turnover. Myosin heads in the SRX state are bound to each other along the thick filament core producing a highly ordered arrangement. Upon activation, these heads project into the interfilament space where they can bind to the actin filaments. Thus far, the population and lifetimes of myosin heads in the SRX state have been characterised in rabbit cardiac, and fast and slow skeletal muscle, as well as in the skeletal muscle of the tarantula. These studies suggest that the role of SRX in cardiac and skeletal muscle regulation is tailored to their specific functions. In skeletal muscle, the SRX modulates the resting metabolic rate. Cardiac SRX represents a ?reserve? of inactive myosin heads that may protect the heart during times of stress, e.g. hypoxia and ischaemia. These heads may also be called up when there is a sustained demand for increased power. The SRX in cardiac muscle provides a potential target for novel therapies. äThe role of super-relaxed myosin in skeletal and cardiac muscle (epmc).pdf DeepDyve Pubget Overpricing