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10.1007/s12551-013-0128-9 http://scihub22266oqcxt.onion/10.1007/s12551-013-0128-9 C5425709!5425709!28509959     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+Rev 2014 ; 6 (1): 47-61 Nephropedia Template TP {{tp|p=28509959|t=2014. Membrane changes under oxidative stress: the impact of oxidized lipids |pdf=|usr=}}{{28509959}} gab.com Text Membrane changes under oxidative stress: the impact of oxidized lipids JO: Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28509959 #FOAvip Studying photosensitized oxidation of unsaturated phospholipids is of importance for understanding the basic processes underlying photodynamic therapy, photoaging and many other biological dysfunctions. In this review we show that the giant unilamellar vesicle, when used as a simplified model of biological membranes, is a powerful tool to investigate how in situ photogenerated oxidative species impact the phospholipid bilayer. The extent of membrane damage can be modulated by choosing a specific photosensitizer (PS) which is activated by light irradiation and can react by either type I and or type II mechanism. We will show that type II PS generates only singlet oxygen which reacts to the phospholipid acyl double bond. The byproduct thus formed is a lipid hydroperoxide which accumulates in the membrane as a function of singlet oxygen production and induces an increase in its area without significantly affecting membrane permeability. The presence of a lipid hydroperoxide can also play an important role in the formation of the lipid domain for mimetic plasma membranes. Lipid hydroperoxides can be also transformed in shortened chain compounds, such as aldehydes and carboxylic acids, in the presence of a PS that reacts via the type I mechanism. The presence of such byproducts may form hydrophilic pores in the membrane for moderate oxidative stress or promote membrane disruption for massive oxidation. Our results provide a new tool to explore membrane response to an oxidative stress and may have implications in biological signaling of redox misbalance. Twit Text FOAVip Membrane changes under oxidative stress: the impact of oxidized lipids ????Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28509959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28509959 #FOAvip English Wikipedia <ref>{{Cite pmid|28509959}}</ref> Membrane changes under oxidative stress: the impact of oxidized lipids #MMPMID28509959 Itri R; Junqueira HC; Mertins O; Baptista MS Biophys Rev 2014[Mar]; 6 (1): 47-61 PMID28509959show ga Studying photosensitized oxidation of unsaturated phospholipids is of importance for understanding the basic processes underlying photodynamic therapy, photoaging and many other biological dysfunctions. In this review we show that the giant unilamellar vesicle, when used as a simplified model of biological membranes, is a powerful tool to investigate how in situ photogenerated oxidative species impact the phospholipid bilayer. The extent of membrane damage can be modulated by choosing a specific photosensitizer (PS) which is activated by light irradiation and can react by either type I and or type II mechanism. We will show that type II PS generates only singlet oxygen which reacts to the phospholipid acyl double bond. The byproduct thus formed is a lipid hydroperoxide which accumulates in the membrane as a function of singlet oxygen production and induces an increase in its area without significantly affecting membrane permeability. The presence of a lipid hydroperoxide can also play an important role in the formation of the lipid domain for mimetic plasma membranes. Lipid hydroperoxides can be also transformed in shortened chain compounds, such as aldehydes and carboxylic acids, in the presence of a PS that reacts via the type I mechanism. The presence of such byproducts may form hydrophilic pores in the membrane for moderate oxidative stress or promote membrane disruption for massive oxidation. Our results provide a new tool to explore membrane response to an oxidative stress and may have implications in biological signaling of redox misbalance. äMembrane changes under oxidative stress: the impact of oxidized lipids(epmc).pdf DeepDyve Pubget Overpricing