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10.1016/j.stemcr.2017.03.018 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2017.03.018 C5425659!5425659!28434939     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2017 ; 8 (5): 1299-311 Nephropedia Template TP {{tp|p=28434939|t=2017. Calreticulin Is Required for TGF-?-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells |pdf=|usr=}}{{28434939}} gab.com Text Calreticulin Is Required for TGF- -Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28434939 #FOAvip Calreticulin, a multifunctional endoplasmic reticulum resident protein, is required for TGF-?-induced epithelial-to-mesenchymal transition (EMT) and subsequent cardiomyogenesis. Using embryoid bodies (EBs) derived from calreticulin-null and wild-type (WT) embryonic stem cells (ESCs), we show that expression of EMT and cardiac differentiation markers is induced during differentiation of WT EBs. This induction is inhibited in the absence of calreticulin and can be mimicked by inhibiting TGF-? signaling in WT cells. The presence of calreticulin in WT cells permits TGF-?-mediated signaling via AKT/GSK3? and promotes repression of E-cadherin by SNAIL2/SLUG. This is paralleled by induction of N-cadherin in a process known as the cadherin switch. We show that regulated Ca2+ signaling between calreticulin and calcineurin is critical for the unabated TGF-? signaling that is necessary for the exit from pluripotency and the cadherin switch during EMT. Calreticulin is thus a key mediator of TGF-?-induced commencement of cardiomyogenesis in mouse ESCs. Twit Text FOAVip Calreticulin Is Required for TGF- -Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28434939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28434939 #FOAvip English Wikipedia <ref>{{Cite pmid|28434939}}</ref> Calreticulin Is Required for TGF-?-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells #MMPMID28434939 Karimzadeh F; Opas M Stem Cell Reports 2017[May]; 8 (5): 1299-311 PMID28434939show ga Calreticulin, a multifunctional endoplasmic reticulum resident protein, is required for TGF-?-induced epithelial-to-mesenchymal transition (EMT) and subsequent cardiomyogenesis. Using embryoid bodies (EBs) derived from calreticulin-null and wild-type (WT) embryonic stem cells (ESCs), we show that expression of EMT and cardiac differentiation markers is induced during differentiation of WT EBs. This induction is inhibited in the absence of calreticulin and can be mimicked by inhibiting TGF-? signaling in WT cells. The presence of calreticulin in WT cells permits TGF-?-mediated signaling via AKT/GSK3? and promotes repression of E-cadherin by SNAIL2/SLUG. This is paralleled by induction of N-cadherin in a process known as the cadherin switch. We show that regulated Ca2+ signaling between calreticulin and calcineurin is critical for the unabated TGF-? signaling that is necessary for the exit from pluripotency and the cadherin switch during EMT. Calreticulin is thus a key mediator of TGF-?-induced commencement of cardiomyogenesis in mouse ESCs. äCalreticulin Is Required for TGF-?-Induced Epithelial-to-Mesenchymal T(epmc).pdf DeepDyve Pubget Overpricing