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10.1007/s00018-017-2467-3 http://scihub22266oqcxt.onion/10.1007/s00018-017-2467-3 C5425506!5425506!28168446     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2017 ; 74 (12): 2217-28 Nephropedia Template TP {{tp|p=28168446|t=2017. Comparing the rules of engagement of androgen and glucocorticoid receptors |pdf=|usr=}}{{28168446}} gab.com Text Comparing the rules of engagement of androgen and glucocorticoid receptors JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28168446 #FOAvip Despite the diverse physiological activities of androgens and glucocorticoids, the corresponding receptors are very close members of the nuclear-receptor super family. Their action mechanisms show striking similarities, since both receptors recognize very similar DNA-response elements and recruit the same coactivators to their target genes. The specificity of the responses lies mainly in the tissue-specific expression of the receptors and in their ligand specificity. In cells, where both receptors are expressed, the mechanisms leading to the difference in target genes are less obvious. They lie in part in subtle variations of the DNA-binding sites, in cooperativity with other transcription factors and in differential allosteric signals from the DNA and ligand to other receptor domains. We will highlight the different suggestions that might explain the DNA sequence selectivity and will compare the possible allosteric routes between the response elements and the different functions in the transactivation process. The interplay of androgen and glucocorticoid receptors is also highly relevant in clinical settings, where both receptors are therapeutically targeted. We will discuss the possibility that the glucocorticoid and androgen receptors can play partially redundant roles in castration-resistant prostate cancer. Twit Text FOAVip Comparing the rules of engagement of androgen and glucocorticoid receptors ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28168446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28168446 #FOAvip English Wikipedia <ref>{{Cite pmid|28168446}}</ref> Comparing the rules of engagement of androgen and glucocorticoid receptors #MMPMID28168446 Claessens F; Joniau S; Helsen C Cell Mol Life Sci 2017[]; 74 (12): 2217-28 PMID28168446show ga Despite the diverse physiological activities of androgens and glucocorticoids, the corresponding receptors are very close members of the nuclear-receptor super family. Their action mechanisms show striking similarities, since both receptors recognize very similar DNA-response elements and recruit the same coactivators to their target genes. The specificity of the responses lies mainly in the tissue-specific expression of the receptors and in their ligand specificity. In cells, where both receptors are expressed, the mechanisms leading to the difference in target genes are less obvious. They lie in part in subtle variations of the DNA-binding sites, in cooperativity with other transcription factors and in differential allosteric signals from the DNA and ligand to other receptor domains. We will highlight the different suggestions that might explain the DNA sequence selectivity and will compare the possible allosteric routes between the response elements and the different functions in the transactivation process. The interplay of androgen and glucocorticoid receptors is also highly relevant in clinical settings, where both receptors are therapeutically targeted. We will discuss the possibility that the glucocorticoid and androgen receptors can play partially redundant roles in castration-resistant prostate cancer. äComparing the rules of engagement of androgen and glucocorticoid recep(epmc).pdf DeepDyve Pubget Overpricing