Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bpj.2017.02.027 http://scihub22266oqcxt.onion/10.1016/j.bpj.2017.02.027 C5425358!5425358!28494966     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2017 ; 112 (9): 1962-74 Nephropedia Template TP {{tp|p=28494966|t=2017. Mechanotransduction Dynamics at the Cell-Matrix Interface |pdf=|usr=}}{{28494966}} gab.com Text Mechanotransduction Dynamics at the Cell-Matrix Interface JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=28494966 #FOAvip The ability of cells to sense and respond to mechanical cues from the surrounding environment has been implicated as a key regulator of cell differentiation, migration, and proliferation. The extracellular matrix (ECM) is an oft-overlooked component of the interface between cells and their surroundings. Cells assemble soluble ECM proteins into insoluble fibrils with unique mechanical properties that can alter the mechanical cues a cell receives. In this study, we construct a model that predicts the dynamics of cellular traction force generation and subsequent assembly of fibrils of the ECM protein fibronectin (FN). FN fibrils are the primary component in primordial ECM and, as such, FN assembly is a critical component in the cellular mechanical response. The model consists of a network of Hookean springs, each representing an extensible domain within an assembling FN fibril. As actomyosin forces stretch the spring network, simulations predict the resulting traction force and FN fibril formation. The model accurately predicts FN fibril morphometry and demonstrates a mechanism by which FN fibril assembly regulates traction force dynamics in response to mechanical stimuli and varying surrounding substrate stiffness. Twit Text FOAVip Mechanotransduction Dynamics at the Cell-Matrix Interface ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=28494966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28494966 #FOAvip English Wikipedia <ref>{{Cite pmid|28494966}}</ref> Mechanotransduction Dynamics at the Cell-Matrix Interface #MMPMID28494966 Weinberg SH; Mair DB; Lemmon CA Biophys J 2017[May]; 112 (9): 1962-74 PMID28494966show ga The ability of cells to sense and respond to mechanical cues from the surrounding environment has been implicated as a key regulator of cell differentiation, migration, and proliferation. The extracellular matrix (ECM) is an oft-overlooked component of the interface between cells and their surroundings. Cells assemble soluble ECM proteins into insoluble fibrils with unique mechanical properties that can alter the mechanical cues a cell receives. In this study, we construct a model that predicts the dynamics of cellular traction force generation and subsequent assembly of fibrils of the ECM protein fibronectin (FN). FN fibrils are the primary component in primordial ECM and, as such, FN assembly is a critical component in the cellular mechanical response. The model consists of a network of Hookean springs, each representing an extensible domain within an assembling FN fibril. As actomyosin forces stretch the spring network, simulations predict the resulting traction force and FN fibril formation. The model accurately predicts FN fibril morphometry and demonstrates a mechanism by which FN fibril assembly regulates traction force dynamics in response to mechanical stimuli and varying surrounding substrate stiffness. äMechanotransduction Dynamics at the Cell-Matrix Interface (epmc).pdf DeepDyve Pubget Overpricing