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10.1126/sciadv.1602272 http://scihub22266oqcxt.onion/10.1126/sciadv.1602272 C5425237!5425237 !28508055     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28508055 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Adv 2017 ; 3 (5 ): e1602272 Nephropedia Template TP {{tp|p=28508055 |t=2017. Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K(+) channels in parkinsonian discharges |pdf=|usr=}}{{28508055 }} gab.com Text Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K(+) channels in parkinsonian discharges JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=28508055 #FOAvip ERG K(+) channels have long been known to play a crucial role in shaping cardiac action potentials and, thus, appropriate heart rhythms. The functional role of ERG channels in the central nervous system, however, remains elusive. We demonstrated that ERG channels exist in subthalamic neurons and have similar gating characteristics to those in the heart. ERG channels contribute crucially not only to the setting of membrane potential and, consequently, the firing modes, but also to the configuration of burst discharges and, consequently, the firing frequency and automaticity of the subthalamic neurons. Moreover, modulation of subthalamic discharges via ERG channels effectively modulates locomotor behaviors. ERG channel inhibitors ameliorate parkinsonian symptoms, whereas enhancers render normal animals hypokinetic. Thus, ERG K(+) channels could be vital to the regulation of both cardiac and neuronal rhythms and may constitute an important pathophysiological basis and pharmacotherapeutic target for the growing list of neurological disorders related to "brain arrhythmias." Twit Text FOAVip Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K(+) channels in parkinsonian discharges ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=28508055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28508055 #FOAvip English Wikipedia <ref>{{Cite pmid|28508055 }}</ref> Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K(+) channels in parkinsonian discharges #MMPMID28508055 Huang CS ; Wang GH ; Tai CH ; Hu CC ; Yang YC Sci Adv 2017[May]; 3 (5 ): e1602272 PMID28508055 show ga ERG K(+) channels have long been known to play a crucial role in shaping cardiac action potentials and, thus, appropriate heart rhythms. The functional role of ERG channels in the central nervous system, however, remains elusive. We demonstrated that ERG channels exist in subthalamic neurons and have similar gating characteristics to those in the heart. ERG channels contribute crucially not only to the setting of membrane potential and, consequently, the firing modes, but also to the configuration of burst discharges and, consequently, the firing frequency and automaticity of the subthalamic neurons. Moreover, modulation of subthalamic discharges via ERG channels effectively modulates locomotor behaviors. ERG channel inhibitors ameliorate parkinsonian symptoms, whereas enhancers render normal animals hypokinetic. Thus, ERG K(+) channels could be vital to the regulation of both cardiac and neuronal rhythms and may constitute an important pathophysiological basis and pharmacotherapeutic target for the growing list of neurological disorders related to "brain arrhythmias." |Animals [MESH] |Anti-Arrhythmia Agents/*pharmacology [MESH] |Behavior, Animal/drug effects [MESH] |Brain Waves/drug effects [MESH] |Ether-A-Go-Go Potassium Channels/*antagonists & inhibitors/metabolism [MESH] |Locomotion/drug effects [MESH] |Parkinson Disease, Secondary/*drug therapy/metabolism/pathology/physiopathology [MESH] |Potassium Channel Blockers/*pharmacology [MESH] |Rats [MESH] |Rats, Wistar [MESH]Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalam(epmc).pdf DeepDyve Pubget Overpricing