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10.1038/ncomms15278 http://scihub22266oqcxt.onion/10.1038/ncomms15278 C5424160!5424160!28474697     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28474697|t=2017. Menin enhances c-Myc-mediated transcription to promote cancer progression |pdf=|usr=}}{{28474697}} gab.com Text Menin enhances c-Myc-mediated transcription to promote cancer progression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28474697 #FOAvip Menin is an enigmatic protein that displays unique ability to either suppress or promote tumorigenesis in a context-dependent manner. The role for Menin to promote oncogenic functions has been largely attributed to its essential role in forming the MLL methyltransferase complex, which mediates H3K4me3. Here, we identify an unexpected role of Menin in enhancing the transactivity of oncogene MYC in a way independent of H3K4me3 activity. Intriguingly, we find that Menin interacts directly with the TAD domain of MYC and co-localizes with MYC to E-Box to enhance the transcription of MYC target genes in a P-TEFb-dependent manner. We further demonstrate that, by transcriptionally promoting the expression of MYC target genes in cancer cells, Menin stimulates cell proliferation and cellular metabolism both in vitro and in vivo. Our results uncover a previously unappreciated mechanism by which Menin functions as an oncogenic regulatory factor that is critical for MYC-mediated gene transcription. Twit Text FOAVip Menin enhances c-Myc-mediated transcription to promote cancer progression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28474697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28474697 #FOAvip English Wikipedia <ref>{{Cite pmid|28474697}}</ref> Menin enhances c-Myc-mediated transcription to promote cancer progression #MMPMID28474697 Wu G; Yuan M; Shen S; Ma X; Fang J; Zhu L; Sun L; Liu Z; He X; Huang D; Li T; Li C; Wu J; Hu X; Li Z; Song L; Qu K; Zhang H; Gao P Nat Commun 2017[]; 8 (ä): ä PMID28474697show ga Menin is an enigmatic protein that displays unique ability to either suppress or promote tumorigenesis in a context-dependent manner. The role for Menin to promote oncogenic functions has been largely attributed to its essential role in forming the MLL methyltransferase complex, which mediates H3K4me3. Here, we identify an unexpected role of Menin in enhancing the transactivity of oncogene MYC in a way independent of H3K4me3 activity. Intriguingly, we find that Menin interacts directly with the TAD domain of MYC and co-localizes with MYC to E-Box to enhance the transcription of MYC target genes in a P-TEFb-dependent manner. We further demonstrate that, by transcriptionally promoting the expression of MYC target genes in cancer cells, Menin stimulates cell proliferation and cellular metabolism both in vitro and in vivo. Our results uncover a previously unappreciated mechanism by which Menin functions as an oncogenic regulatory factor that is critical for MYC-mediated gene transcription. äMenin enhances c-Myc-mediated transcription to promote cancer progress(epmc).pdf DeepDyve Pubget Overpricing