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10.1038/oncsis.2014.2 http://scihub22266oqcxt.onion/10.1038/oncsis.2014.2 C5424097!5424097!24566388     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2014 ; 3 (2): e89- Nephropedia Template TP {{tp|p=24566388|t=2014. The essential role of TNIK gene amplification in gastric cancer growth |pdf=|usr=}}{{24566388}} gab.com Text The essential role of TNIK gene amplification in gastric cancer growth JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=24566388 #FOAvip Traf2- and Nck-interacting kinase (TNIK) is one of the germinal center kinase family members involved in cytoskeleton organization and neuronal dendrite extension. Emerging evidence supports that TNIK is essential for activation of WNT signaling pathway in colon cancer growth. To search for novel genetic aberrations that drive carcinogenesis, we performed microarray-based comparative hybridization assay for gene copy number variations in primary tumor samples. Our data showed that TNIK gene was amplified in 7% (8/106) of Chinese gastric cancer patients. Theses amplifications were confirmed by fluorescence in situ hybridization analysis. PAMC82 human gastric cancer and T47D human breast cancer cell lines with TNIK amplification were identified to further understand the function of TNIK gene amplification. RNA-interference-mediated silencing of TNIK resulted in significant inhibition of cell growth and induction of cell death in TNIK-amplified, but not in TNIK-non-amplified, cell lines tested. This selective sensitivity to the TNIK inhibition was also observed under the effect of a small-molecule TNIK inhibitor. Furthermore, our data indicated that TNIK's role in gastric cancer growth was not dependent on Wnt signaling but rather was involved in AKT activation and cell autophagy. Together, our results suggest that TNIK is a novel therapeutic target in gastric cancer and TNIK amplification can be potentially used for patient selection. Twit Text FOAVip The essential role of TNIK gene amplification in gastric cancer growth ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=24566388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24566388 #FOAvip English Wikipedia <ref>{{Cite pmid|24566388}}</ref> The essential role of TNIK gene amplification in gastric cancer growth #MMPMID24566388 Yu DH; Zhang X; Wang H; Zhang L; Chen H; Hu M; Dong Z; Zhu G; Qian Z; Fan J; Su X; Xu Y; Zheng L; Dong H; Yin X; Ji Q; Ji J Oncogenesis 2014[Feb]; 3 (2): e89- PMID24566388show ga Traf2- and Nck-interacting kinase (TNIK) is one of the germinal center kinase family members involved in cytoskeleton organization and neuronal dendrite extension. Emerging evidence supports that TNIK is essential for activation of WNT signaling pathway in colon cancer growth. To search for novel genetic aberrations that drive carcinogenesis, we performed microarray-based comparative hybridization assay for gene copy number variations in primary tumor samples. Our data showed that TNIK gene was amplified in 7% (8/106) of Chinese gastric cancer patients. Theses amplifications were confirmed by fluorescence in situ hybridization analysis. PAMC82 human gastric cancer and T47D human breast cancer cell lines with TNIK amplification were identified to further understand the function of TNIK gene amplification. RNA-interference-mediated silencing of TNIK resulted in significant inhibition of cell growth and induction of cell death in TNIK-amplified, but not in TNIK-non-amplified, cell lines tested. This selective sensitivity to the TNIK inhibition was also observed under the effect of a small-molecule TNIK inhibitor. Furthermore, our data indicated that TNIK's role in gastric cancer growth was not dependent on Wnt signaling but rather was involved in AKT activation and cell autophagy. Together, our results suggest that TNIK is a novel therapeutic target in gastric cancer and TNIK amplification can be potentially used for patient selection. äThe essential role of TNIK gene amplification in gastric cancer growth(epmc).pdf DeepDyve Pubget Overpricing