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10.1371/journal.pone.0172581 http://scihub22266oqcxt.onion/10.1371/journal.pone.0172581 C5423601!5423601 !28486523     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28486523 &cmd=llinks): Failed to open stream: HTTP request failed! 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Barriers towards the publication of academic drug trials Follow-up of trials approved by the Danish Medicines Agency |pdf=|usr=}}{{28486523 }} gab.com Text Barriers towards the publication of academic drug trials Follow-up of trials approved by the Danish Medicines Agency JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28486523 #FOAvip OBJECTIVE: To characterize and quantify barriers towards the publication of academic drug trials. STUDY DESIGN: We identified academic drug trials approved during a 3-year period (2004-2007) by the Danish Medicines Agency. We conducted a survey among the trial sponsors to describe the rates of initiation, completion, and publication, and the reasons for the failure to reach each of these milestones. Information on size and methodological characteristics of the trials was extracted from the EudraCT database, a prospective register of all approved clinical drug trials submitted to European medicines agencies since 2004. RESULTS: A total of 181 academic drug trials were eligible for inclusion, 139 of which participated in our survey (response rate: 77%). Follow-up time ranged from 5.1 to 7.9 years. Most trials were randomized controlled trials (73%, 95% CI 65-81%). Initiation and completion rates were 92% (95% CI: 88-97%) and 93% (95% CI: 89-97%) respectively. The publication rate of completed trials was 73% (95% CI: 62-79%). RCTs were published faster than non-RCTs (quartile time to publication 2.9 vs. 3.1 years, p = 0.0412). CONCLUSIONS: Many academic drug trials are left unpublished. Main barriers towards publication were related to the process from completion to publication. Hence, there is much to gain by facilitating the process from analysis to publication. Research institutions and funders should actively influence this process, e.g. by requiring the publication of trial results within a given time after completion. Twit Text FOAVip Barriers towards the publication of academic drug trials Follow-up of trials approved by the Danish Medicines Agency ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28486523 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28486523 #FOAvip English Wikipedia <ref>{{Cite pmid|28486523 }}</ref> Barriers towards the publication of academic drug trials Follow-up of trials approved by the Danish Medicines Agency #MMPMID28486523 Berendt L ; Petersen LG ; Bach KF ; Poulsen HE ; Dalhoff K PLoS One 2017[]; 12 (5 ): e0172581 PMID28486523 show ga OBJECTIVE: To characterize and quantify barriers towards the publication of academic drug trials. STUDY DESIGN: We identified academic drug trials approved during a 3-year period (2004-2007) by the Danish Medicines Agency. We conducted a survey among the trial sponsors to describe the rates of initiation, completion, and publication, and the reasons for the failure to reach each of these milestones. Information on size and methodological characteristics of the trials was extracted from the EudraCT database, a prospective register of all approved clinical drug trials submitted to European medicines agencies since 2004. RESULTS: A total of 181 academic drug trials were eligible for inclusion, 139 of which participated in our survey (response rate: 77%). Follow-up time ranged from 5.1 to 7.9 years. Most trials were randomized controlled trials (73%, 95% CI 65-81%). Initiation and completion rates were 92% (95% CI: 88-97%) and 93% (95% CI: 89-97%) respectively. The publication rate of completed trials was 73% (95% CI: 62-79%). RCTs were published faster than non-RCTs (quartile time to publication 2.9 vs. 3.1 years, p = 0.0412). CONCLUSIONS: Many academic drug trials are left unpublished. Main barriers towards publication were related to the process from completion to publication. Hence, there is much to gain by facilitating the process from analysis to publication. Research institutions and funders should actively influence this process, e.g. by requiring the publication of trial results within a given time after completion. |*Drug Evaluation [MESH] |*Government Agencies [MESH] |*Publications [MESH] |Databases, Factual [MESH] |Denmark [MESH]Barriers towards the publication of academic drug trials Follow-up of(epmc).pdf DeepDyve Pubget Overpricing