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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 PLoS+One
2017 ; 12
(5
): e0176549
Nephropedia Template TP
gab.com Text
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English Wikipedia
Association between a history of mycobacterial infection and the risk of newly
diagnosed Sjögren s syndrome: A nationwide, population-based case-control study
#MMPMID28486537
Chao WC
; Lin CH
; Liao TL
; Chen YM
; Chen DY
; Chen HH
PLoS One
2017[]; 12
(5
): e0176549
PMID28486537
show ga
OBJECTIVE: To address the association between a history of tuberculosis (TB) or
nontuberculous mycobacterial (NTM) infection and the risk of newly diagnosed
Sjögren's syndrome (SS). METHODS: Using a nationwide, population-based, claims
dataset, and after excluding those who had rheumatoid arthritis or systemic lupus
erythematosus, we identified 5,751 newly diagnosed SS cases during 2007-2012, and
compared them to 86,265 non-SS controls matched (1:15) for age, sex, and the year
of first SS diagnosis date. The association between the risk of incident SS and a
history of mycobacterial infection, including TB and NTM, was quantified by
calculating odds ratios (ORs) with 95% confidence intervals (CIs) using
conditional logistic regression analysis after adjustment for Charlson
comorbidity index (CCI) and bronchiectasis. RESULTS: The mean age was 55±14
years, and the proportion of female gender was 87.8% in both newly diagnosed SS
cases andnon-SS controls. An association was observed between NTM infection (OR,
11.24; 95% CI, 2.37-53.24) and incident SS, but not between TB infection and
incident SS (OR, 1.29; 95% CI, 0.97-1.71) after adjustment for CCI and
bronchiectasis. The association between NTM and SS risk was remarkably strong
among those aged between 45 and 65 years (OR, 39.24; 95% CI, 3.97-387.75) and
those without bronchiectasis (OR, 39.98; 95% CI, 3.83-376.92). CONCLUSION: The
study reveals a significant association of newly diagnosed SS with a history NTM
infection, especially among individuals aged 40-65 years or those without
bronchiectasis.