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10.1371/journal.pone.0176549

http://scihub22266oqcxt.onion/10.1371/journal.pone.0176549
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suck abstract from ncbi


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pmid28486537
      PLoS+One 2017 ; 12 (5 ): e0176549
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  • Association between a history of mycobacterial infection and the risk of newly diagnosed Sjögren s syndrome: A nationwide, population-based case-control study #MMPMID28486537
  • Chao WC ; Lin CH ; Liao TL ; Chen YM ; Chen DY ; Chen HH
  • PLoS One 2017[]; 12 (5 ): e0176549 PMID28486537 show ga
  • OBJECTIVE: To address the association between a history of tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection and the risk of newly diagnosed Sjögren's syndrome (SS). METHODS: Using a nationwide, population-based, claims dataset, and after excluding those who had rheumatoid arthritis or systemic lupus erythematosus, we identified 5,751 newly diagnosed SS cases during 2007-2012, and compared them to 86,265 non-SS controls matched (1:15) for age, sex, and the year of first SS diagnosis date. The association between the risk of incident SS and a history of mycobacterial infection, including TB and NTM, was quantified by calculating odds ratios (ORs) with 95% confidence intervals (CIs) using conditional logistic regression analysis after adjustment for Charlson comorbidity index (CCI) and bronchiectasis. RESULTS: The mean age was 55±14 years, and the proportion of female gender was 87.8% in both newly diagnosed SS cases andnon-SS controls. An association was observed between NTM infection (OR, 11.24; 95% CI, 2.37-53.24) and incident SS, but not between TB infection and incident SS (OR, 1.29; 95% CI, 0.97-1.71) after adjustment for CCI and bronchiectasis. The association between NTM and SS risk was remarkably strong among those aged between 45 and 65 years (OR, 39.24; 95% CI, 3.97-387.75) and those without bronchiectasis (OR, 39.98; 95% CI, 3.83-376.92). CONCLUSION: The study reveals a significant association of newly diagnosed SS with a history NTM infection, especially among individuals aged 40-65 years or those without bronchiectasis.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Case-Control Studies [MESH]
  • |Confounding Factors, Epidemiologic [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Mycobacterium Infections/*complications/epidemiology [MESH]
  • |Risk Factors [MESH]
  • |Sjogren's Syndrome/*complications/epidemiology [MESH]


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