A link between transcription fidelity and pausing in vivo #MMPMID28072558
Gamba P; James K; Zenkin N
Transcription 2017[]; 8 (2): 99-105 PMID28072558show ga
Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source of transcription pausing in vivo, and discuss the role of misincorporation-induced pausing.