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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Renal+Inj+Prev
2017 ; 6
(2
): 109-112
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Evaluation of water and electrolytes disorders in severe acute diarrhea patients
treated by WHO protocol in eight large hospitals in Tehran; a nephrology
viewpoint
#MMPMID28497085
Soleimani A
; Foroozanfard F
; Tamadon MR
J Renal Inj Prev
2017[]; 6
(2
): 109-112
PMID28497085
show ga
Introduction: The most common cause of death from diarrhea is the shock caused by
dehydration, electrolytes and acid-base disorders. Objectives: The aim of this
study was to evaluate water and electrolytes disorders in diarrhea patients after
treating severe acute diarrhea. Patients and Methods: In this study we used a
historical cohort and studied patients who were hospitalized due to acute
diarrhea and were similarly treated for dehydration and water and electrolyte
disorders as recommended by the World Health Organization (WHO) guideline.
Electrolytes, pH, serum creatinine (Cr) level on admission and during treatment
were recorded. Patients with underlying diseases were excluded from the study.
Results: Of 121 patients who were enrolled in the study, 67.8% had hyponatremia
on admission (plasma Na <137 mEq/L) and 5.8% had hypernatremia. Around, 33.88% of
patients had hypokalemia and 2.4% had hyperkalemia. All hyperkalemia disorders
were treated, but 87.1% of patients had hypokalemia or low potassium levels, or
they were affected by uncorrected hypokalemia and were in need of further
measures. Of all, 56.75% had acidosis and 21% of patients with acidosis were not
treated or the severity of their acidosis increased during treatment. There was a
significant relationship between acute renal failure (ARF) and hypokalemia at the
time of admission (P<0.001), potassium loss during treatment (P<0.001), acidosis
(0.005), and cholera-related diarrhea (0.05). Conclusion: The high prevalence of
hypokalemia in these patients as well as potassium loss during treatment
indicates insufficient level of potassium in the therapeutic solutions. Mild
hyponatremia in most patients highlights the need for isotonic solutions to treat
dehydration.