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10.1038/cdd.2017.9 http://scihub22266oqcxt.onion/10.1038/cdd.2017.9 C5423121!5423121 !28186499     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28186499 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Differ 2017 ; 24 (5 ): 785-797 Nephropedia Template TP {{tp|p=28186499 |t=2017. Downregulation of Lnc-Spry1 mediates TGF-?-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms |pdf=|usr=}}{{28186499 }} gab.com Text Downregulation of Lnc-Spry1 mediates TGF- -induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28186499 #FOAvip Long non-coding RNAs (lncRNAs) are a class of regulatory genes that participate in a wide range of biological processes, including proliferation, differentiation and development, as well as in a broad spectrum of diseases. Although the role of lncRNAs in TGF-?-induced epithelial-to-mesenchymal transition (EMT) has been well established, little is known about the role of lncRNAs as immediate-early regulators of EMT. Here lnc-Spry1 is identified as an immediate-early regulator of EMT that is downregulated by TGF-?. It is also found that knockdown of lnc-Spry1 promotes a mesenchymal-like phenotype and results in increased cell migration and invasion. In addition, it is shown that lnc-Spry1 depletion preferentially affects the expression of TGF-?-regulated gene targets. Moreover, lnc-Spry1 associates with U2AF65 splicing factor, suggesting a role in alternative splicing. Depletion of lnc-Spry1 induces, as TGF-?, isoform switching of fibroblast growth factor receptors, resulting in FGF-2-sensitive cells. Taken together, these results show that lnc-Spry1 could act as an early mediator of TGF-? signaling and reveal different roles for a lncRNA in modulating transcriptional and posttranscriptional gene expression. Twit Text FOAVip Downregulation of Lnc-Spry1 mediates TGF- -induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28186499 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28186499 #FOAvip English Wikipedia <ref>{{Cite pmid|28186499 }}</ref> Downregulation of Lnc-Spry1 mediates TGF-?-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms #MMPMID28186499 Rodríguez-Mateo C ; Torres B ; Gutiérrez G ; Pintor-Toro JA Cell Death Differ 2017[May]; 24 (5 ): 785-797 PMID28186499 show ga Long non-coding RNAs (lncRNAs) are a class of regulatory genes that participate in a wide range of biological processes, including proliferation, differentiation and development, as well as in a broad spectrum of diseases. Although the role of lncRNAs in TGF-?-induced epithelial-to-mesenchymal transition (EMT) has been well established, little is known about the role of lncRNAs as immediate-early regulators of EMT. Here lnc-Spry1 is identified as an immediate-early regulator of EMT that is downregulated by TGF-?. It is also found that knockdown of lnc-Spry1 promotes a mesenchymal-like phenotype and results in increased cell migration and invasion. In addition, it is shown that lnc-Spry1 depletion preferentially affects the expression of TGF-?-regulated gene targets. Moreover, lnc-Spry1 associates with U2AF65 splicing factor, suggesting a role in alternative splicing. Depletion of lnc-Spry1 induces, as TGF-?, isoform switching of fibroblast growth factor receptors, resulting in FGF-2-sensitive cells. Taken together, these results show that lnc-Spry1 could act as an early mediator of TGF-? signaling and reveal different roles for a lncRNA in modulating transcriptional and posttranscriptional gene expression. |*RNA Processing, Post-Transcriptional [MESH] |*Transcription, Genetic [MESH] |Adaptor Proteins, Signal Transducing/*genetics/metabolism [MESH] |Animals [MESH] |Cell Line [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Epithelial Cells/cytology/drug effects/metabolism [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Fibroblast Growth Factor 2/genetics/metabolism/pharmacology [MESH] |Mammary Glands, Animal/cytology/drug effects/metabolism [MESH] |Membrane Proteins/*genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mutation [MESH] |Phosphoproteins/*genetics/metabolism [MESH] |RNA, Long Noncoding/*genetics/metabolism [MESH] |Receptors, Fibroblast Growth Factor/genetics/metabolism [MESH] |Signal Transduction [MESH] |Splicing Factor U2AF/genetics/metabolism [MESH]Downregulation of Lnc-Spry1 mediates TGF-?-induced epithelial-mesenchy(epmc).pdf DeepDyve Pubget Overpricing