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10.1038/cdd.2017.50 http://scihub22266oqcxt.onion/10.1038/cdd.2017.50 C5423119!5423119!28387757     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2017 ; 24 (5): 929-43 Nephropedia Template TP {{tp|p=28387757|t=2017. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer |pdf=|usr=}}{{28387757}} gab.com Text GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28387757 #FOAvip Inflammation is frequently associated with initiation, progression, and metastasis of colorectal cancer (CRC). Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1. Using data from a large cohort of clinical samples including inflammatory bowel disease and CRC, and a cellular model of CRC progression mediated by cross-talk between the cancer cell and the inflammatory microenvironment, we identified GFI1 as a gating regulator responsible for a constitutively activated signalling circuit that renders CRC cells competent for metastatic spread. Further analysis of mouse models with metastatic CRC and human clinical specimens reinforced the influence of GFI1 downregulation in promoting CRC metastatic spread. The novel role of GFI1 is uncovered for the first time in a human solid tumour such as CRC. Our results imply that GFI1 is a potential therapeutic target for interfering with inflammation-induced CRC progression and spread. Twit Text FOAVip GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28387757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28387757 #FOAvip English Wikipedia <ref>{{Cite pmid|28387757}}</ref> GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer #MMPMID28387757 Xing W; Xiao Y; Lu X; Zhu H; He X; Huang W; Lopez ES; Wong J; Ju H; Tian L; Zhang F; Xu H; Wang SD; Li X; Karin M; Ren H Cell Death Differ 2017[May]; 24 (5): 929-43 PMID28387757show ga Inflammation is frequently associated with initiation, progression, and metastasis of colorectal cancer (CRC). Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1. Using data from a large cohort of clinical samples including inflammatory bowel disease and CRC, and a cellular model of CRC progression mediated by cross-talk between the cancer cell and the inflammatory microenvironment, we identified GFI1 as a gating regulator responsible for a constitutively activated signalling circuit that renders CRC cells competent for metastatic spread. Further analysis of mouse models with metastatic CRC and human clinical specimens reinforced the influence of GFI1 downregulation in promoting CRC metastatic spread. The novel role of GFI1 is uncovered for the first time in a human solid tumour such as CRC. Our results imply that GFI1 is a potential therapeutic target for interfering with inflammation-induced CRC progression and spread. äGFI1 downregulation promotes inflammation-linked metastasis of colorec(epmc).pdf DeepDyve Pubget Overpricing