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10.1073/pnas.1619386114 http://scihub22266oqcxt.onion/10.1073/pnas.1619386114 C5422814!5422814!28416698     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28416698&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (18): E3689-98 Nephropedia Template TP {{tp|p=28416698|t=2017. Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy |pdf=|usr=}}{{28416698}} gab.com Text Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28416698 #FOAvip Anti-MAG (myelin-associated glycoprotein) neuropathy is a rare but disabling autoimmune disorder affecting the peripheral nervous system. The pathogenicity of anti-MAG IgM autoantibodies that target the HNK-1 glycoepitope is well established. Current therapies are mostly immunosuppressive but so far are neither approved nor sufficiently effective. Therefore we designed a glycopolymer that acts as an autoantibody scavenger by mimicking the natural HNK-1 glycoepitope and demonstrated that the glycopolymer neutralizes disease-causing antibodies in patient sera. Moreover, pathogenic antibodies were removed efficiently in an immunological mouse model of anti-MAG neuropathy. Because clinical improvement of patients? neuropathic symptoms correlates with reduced serum levels of anti-MAG antibodies, the glycopolymer represents a promising antigen-specific therapeutic option for the treatment of this neuropathy. Twit Text FOAVip Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28416698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28416698 #FOAvip English Wikipedia <ref>{{Cite pmid|28416698}}</ref> Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy #MMPMID28416698 Herrendorff R; Hänggi P; Pfister H; Yang F; Demeestere D; Hunziker F; Frey S; Schaeren-Wiemers N; Steck AJ; Ernst B Proc Natl Acad Sci U S A 2017[May]; 114 (18): E3689-98 PMID28416698show ga Anti-MAG (myelin-associated glycoprotein) neuropathy is a rare but disabling autoimmune disorder affecting the peripheral nervous system. The pathogenicity of anti-MAG IgM autoantibodies that target the HNK-1 glycoepitope is well established. Current therapies are mostly immunosuppressive but so far are neither approved nor sufficiently effective. Therefore we designed a glycopolymer that acts as an autoantibody scavenger by mimicking the natural HNK-1 glycoepitope and demonstrated that the glycopolymer neutralizes disease-causing antibodies in patient sera. Moreover, pathogenic antibodies were removed efficiently in an immunological mouse model of anti-MAG neuropathy. Because clinical improvement of patients? neuropathic symptoms correlates with reduced serum levels of anti-MAG antibodies, the glycopolymer represents a promising antigen-specific therapeutic option for the treatment of this neuropathy. äSelective in vivo removal of pathogenic anti-MAG autoantibodies, an an(epmc).pdf DeepDyve Pubget Overpricing