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10.5483/bmbrep.2017.50.3.223 http://scihub22266oqcxt.onion/10.5483/bmbrep.2017.50.3.223 C5422028!5422028 !28256196     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28256196 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMB+Rep 2017 ; 50 (3 ): 150-155 Nephropedia Template TP {{tp|p=28256196 |t=2017. Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways |pdf=|usr=}}{{28256196 }} gab.com Text Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=28256196 #FOAvip Non-small-cell lung cancer (NSCLC) is the third most common cancer that spreads to the bone, resulting in osteolytic lesions caused by hyperactivation of osteoclasts. Activating mutations in epidermal growth factor receptor-tyrosine kinase (EGF-TK) are frequently associated with NSCLC, and afatinib is a first-line therapeutic drug, irreversibly targeting EGF-TK. However, the effects of afatinib on osteoclast differentiation and activation as well as the underlying mechanism remain unclear. In this study, afatinib significantly suppressed receptor activator of nuclear factor ?B (RANK) ligand (RANKL)-induced osteoclast formation in bone marrow macrophages (BMMs). Consistently, afatinib inhibited the expression of osteoclast marker genes, whereas, it upregulated the expression of negative modulator genes. The bone resorbing activity of osteoclasts was also abrogated by afatinib. In addition, afatinib significantly inhibited RANKL-mediated Akt/protein kinase B and c-Jun N-terminal kinase phosphorylation. These results suggest that afatinib substantially suppresses osteoclastogenesis by downregulating RANK signaling pathways, and thus may reduce osteolysis after bone metastasis. [BMB Reports 2017; 50(3): 150-155]. Twit Text FOAVip Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=28256196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28256196 #FOAvip English Wikipedia <ref>{{Cite pmid|28256196 }}</ref> Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways #MMPMID28256196 Ihn HJ ; Kim JA ; Bae YC ; Shin HI ; Baek MC ; Park EK BMB Rep 2017[Mar]; 50 (3 ): 150-155 PMID28256196 show ga Non-small-cell lung cancer (NSCLC) is the third most common cancer that spreads to the bone, resulting in osteolytic lesions caused by hyperactivation of osteoclasts. Activating mutations in epidermal growth factor receptor-tyrosine kinase (EGF-TK) are frequently associated with NSCLC, and afatinib is a first-line therapeutic drug, irreversibly targeting EGF-TK. However, the effects of afatinib on osteoclast differentiation and activation as well as the underlying mechanism remain unclear. In this study, afatinib significantly suppressed receptor activator of nuclear factor ?B (RANK) ligand (RANKL)-induced osteoclast formation in bone marrow macrophages (BMMs). Consistently, afatinib inhibited the expression of osteoclast marker genes, whereas, it upregulated the expression of negative modulator genes. The bone resorbing activity of osteoclasts was also abrogated by afatinib. In addition, afatinib significantly inhibited RANKL-mediated Akt/protein kinase B and c-Jun N-terminal kinase phosphorylation. These results suggest that afatinib substantially suppresses osteoclastogenesis by downregulating RANK signaling pathways, and thus may reduce osteolysis after bone metastasis. [BMB Reports 2017; 50(3): 150-155]. |Afatinib [MESH] |Animals [MESH] |Bone Marrow Cells/cytology [MESH] |Bone Resorption/pathology [MESH] |Cell Differentiation/drug effects [MESH] |Down-Regulation/drug effects [MESH] |ErbB Receptors/metabolism [MESH] |JNK Mitogen-Activated Protein Kinases/metabolism [MESH] |Macrophages/drug effects [MESH] |Mice [MESH] |NF-kappa B/metabolism [MESH] |Osteoclasts/*cytology [MESH] |Phosphorylation [MESH] |Quinazolines/*metabolism/therapeutic use [MESH] |RANK Ligand/*drug effects/genetics/*metabolism [MESH] |Receptor Activator of Nuclear Factor-kappa B/metabolism [MESH]Afatinib ameliorates osteoclast differentiation and function through (epmc).pdf DeepDyve Pubget Overpricing