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10.18632/oncotarget.15201 http://scihub22266oqcxt.onion/10.18632/oncotarget.15201 C5421967!5421967!28187001     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (15): 25756-82 Nephropedia Template TP {{tp|p=28187001|t=2017. Molecular markers of paragangliomas/pheochromocytomas |pdf=|usr=}}{{28187001}} gab.com Text Molecular markers of paragangliomas/pheochromocytomas JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28187001 #FOAvip Paragangliomas/pheochromocytomas comprise rare tumors that arise from the extra-adrenal paraganglia, with an incidence of about 2 to 8 per million people each year. Approximately 40% of cases are due to genetic mutations in at least one out of more than 30 causative genes. About 2530% of pheochromocytomas/paragangliomas develop under the conditions of a hereditary tumor syndrome a third of which are caused by mutations in the VHL gene. Together, the gene mutations in this disorder have implicated multiple processes including signaling pathways, translation initiation, hypoxia regulation, protein synthesis, differentiation, survival, proliferation, and cell growth. The present review contemplates the mutations associated with the development of pheochromocytomas/paragangliomas and their potential to serve as specific markers of these tumors and their progression. These data will improve our understanding of the pathogenesis of these tumors and likely reveal certain features that may be useful for early diagnostics, malignancy prognostics, and the determination of new targets for disease therapeutics. Twit Text FOAVip Molecular markers of paragangliomas/pheochromocytomas ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28187001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28187001 #FOAvip English Wikipedia <ref>{{Cite pmid|28187001}}</ref> Molecular markers of paragangliomas/pheochromocytomas #MMPMID28187001 Zhikrivetskaya SO; Snezhkina AV; Zaretsky AR; Alekseev BY; Pokrovsky AV; Golovyuk AL; Melnikova NV; Stepanov OA; Kalinin DV; Moskalev AA; Krasnov GS; Dmitriev AA; Kudryavtseva AV Oncotarget 2017[Apr]; 8 (15): 25756-82 PMID28187001show ga Paragangliomas/pheochromocytomas comprise rare tumors that arise from the extra-adrenal paraganglia, with an incidence of about 2 to 8 per million people each year. Approximately 40% of cases are due to genetic mutations in at least one out of more than 30 causative genes. About 2530% of pheochromocytomas/paragangliomas develop under the conditions of a hereditary tumor syndrome a third of which are caused by mutations in the VHL gene. Together, the gene mutations in this disorder have implicated multiple processes including signaling pathways, translation initiation, hypoxia regulation, protein synthesis, differentiation, survival, proliferation, and cell growth. The present review contemplates the mutations associated with the development of pheochromocytomas/paragangliomas and their potential to serve as specific markers of these tumors and their progression. These data will improve our understanding of the pathogenesis of these tumors and likely reveal certain features that may be useful for early diagnostics, malignancy prognostics, and the determination of new targets for disease therapeutics. äMolecular markers of paragangliomas/pheochromocytomas (epmc).pdf DeepDyve Pubget Overpricing