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2017 ; 8
(15
): 25242-25250
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Metformin is associated with survival benefit in pancreatic cancer patients with
diabetes: a systematic review and meta-analysis
#MMPMID28445955
Zhou PT
; Li B
; Liu FR
; Zhang MC
; Wang Q
; Li YY
; Xu C
; Liu YH
; Yao Y
; Li D
Oncotarget
2017[Apr]; 8
(15
): 25242-25250
PMID28445955
show ga
BACKGROUND: Pancreatic cancer is a highly lethal disease with a poor prognosis
while metformin has been associated with a decreased risk of pancreatic cancer.
Although the benefit of metformin was observed for pancreatic cancer prevention,
it is not clear whether it can also affect the survival of pancreatic cancer
patients with type 2 diabetes mellitus. A systematic review and meta-analysis was
conducted to assess the effect of metformin on the survival of pancreatic cancer
patients with type 2 diabetes mellitus. METHODS: Two independent authors searched
PubMed and Web of science up to 08/07/2016. We assessed studies for eligibility,
extracted data, and examined their quality, with the primary outcome as overall
survival. We used published hazard ratio (HR) available or estimated based on
other survival data. We pooled the data and used a random-effect model to combine
direct comparisons from included articles. We also investigated treatment effects
by different countries, quality and the time of metformin initiation. RESULTS: We
found that there was a relative survival benefit associated with metformin
treatment compared with non-metformin treatment in both overall survival (OS)
([HR] 0.84; 95% confidence interval [CI]: 0.73 - 0.96). These associations were
also observed in subgroups of Asian countries and high quality articles.
CONCLUSIONS: Our results support the notion that metformin maybe the best
anti-diabetic medicine of choice in patients with pancreatic cancer and
concurrent type 2 diabetes mellitus. The perspectives of enhancing survival of
pancreatic cancer patients with diabetes mellitus by the use of metformin deserve
more attention in future research and clinical practice.
|Diabetes Mellitus, Type 2/*complications/*drug therapy
[MESH]
free
free
free
