Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28186997
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28186997
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2017 ; 8
(15
): 24828-24839
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Autoantibodies against glucose-regulated protein 78 as serological biomarkers in
metastatic and recurrent hepatocellular carcinoma
#MMPMID28186997
Ying X
; Han SX
; He CC
; Zhou CY
; Dong YP
; Cai MJ
; Sui X
; Ma CX
; Sun X
; Zhang YY
; Gou WL
; Mason C
; Zhu Q
Oncotarget
2017[Apr]; 8
(15
): 24828-24839
PMID28186997
show ga
PURPOSE: To identify Heptocellular carcinoma (HCC) associated antigens by
proteomics, and validate whether autoantibodies against tumor-associated antigens
(TAAs) could be used for diagnosis and conditional monitoring. RESULTS: The 78
kDa glucose regulated protein (GRP78) was selected as a candidate TAA. The titers
of autoantibodies against 78 kDa glucose regulated protein (GRP78) from patients
with HCC, liver cirrhosis (LC), and chronic hepatitis (CH) were significantly
higher than that from normal controls (P<0.05, P<0.001, and P<0.01,
respectively). The expression of autoantibodies against GRP78 was associated with
clinical stage (P<0.01), portal vein invasion (P<0.05), and metastasis (P<0.05).
The expression of anti-GRP78 antibodies was significantly higher 1 month after
surgery in recurrent patients who had accepted hepatic resection 1 month after
surgery compared to patients who had surgery before surgery or within 1 week
after surgery (P<0.01 and P<0.001). Immunohistochemistry (IHC) showed higher
expression of GRP78 in HCC compared to the non-HCC liver tissues (P <0.05).
MATERIALS AND METHODS: HCC serum with high titer of autoantibodies against TAAs
were screened and used for a proteome-based approach to identify HCC associated
antigens. Indirect enzyme-linked immunoassay (ELISA) was used to detect the
corresponding autoantibodies against TAAs. CONCLUSION: GRP78 is an autoantigen
that could stimulate autoimmune responses and serve as a potential marker for
recurrent and metastatic progression in HCC.
free
free
free
