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10.18632/oncotarget.15800 http://scihub22266oqcxt.onion/10.18632/oncotarget.15800 C5421885!5421885!28445970     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (15): 24753-61 Nephropedia Template TP {{tp|p=28445970|t=2017. Acid ceramidase is a novel drug target for pediatric brain tumors |pdf=|usr=}}{{28445970}} gab.com Text Acid ceramidase is a novel drug target for pediatric brain tumors JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28445970 #FOAvip Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tumors, suggesting that acid ceramidase may confer radioresistance. More importantly, we also showed that acid ceramidase inhibitors are highly effective at targeting these pediatric brain tumors with low IC50 values (4.6?50 ?M). This data suggests acid ceramidase as a novel drug target for adjuvant pediatric brain tumor therapies. Of these acid ceramidase inhibitors, carmofur has seen clinical use in Japan since 1981 for colorectal cancers and is a promising drug to undergo further animal studies and subsequently a clinical trial as a treatment for pediatric patients with brain tumors. Twit Text FOAVip Acid ceramidase is a novel drug target for pediatric brain tumors ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28445970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28445970 #FOAvip English Wikipedia <ref>{{Cite pmid|28445970}}</ref> Acid ceramidase is a novel drug target for pediatric brain tumors #MMPMID28445970 Doan NB; Nguyen HS; Montoure A; Al-Gizawiy MM; Mueller WM; Kurpad S; Rand SD; Connelly JM; Chitambar CR; Schmainda KM; Mirza SP Oncotarget 2017[Apr]; 8 (15): 24753-61 PMID28445970show ga Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tumors, suggesting that acid ceramidase may confer radioresistance. More importantly, we also showed that acid ceramidase inhibitors are highly effective at targeting these pediatric brain tumors with low IC50 values (4.6?50 ?M). This data suggests acid ceramidase as a novel drug target for adjuvant pediatric brain tumor therapies. Of these acid ceramidase inhibitors, carmofur has seen clinical use in Japan since 1981 for colorectal cancers and is a promising drug to undergo further animal studies and subsequently a clinical trial as a treatment for pediatric patients with brain tumors. äAcid ceramidase is a novel drug target for pediatric brain tumors (epmc).pdf DeepDyve Pubget Overpricing