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2017 ; 8
(2
): 99-102
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5-Aminosalicylates to maintain remission in Crohn s disease: Interpreting
conflicting systematic review evidence
#MMPMID28533918
Gordon M
World J Gastrointest Pharmacol Ther
2017[May]; 8
(2
): 99-102
PMID28533918
show ga
5-Aminosalicylates are a class of anti-inflammatory agents that have been used
for decades in inflammatory bowel disease. Whilst they are first line for
induction and an option for maintenance of remission in ulcerative colitis, the
picture in Crohn's disease is variable. For maintenance of remission, key
Cochrane systematic reviews have found conflicting results between the medical
and surgical induced contexts. In this piece, the possible reasons for this are
considered. It is proposed that clinicians should consider 5-aminosalicylates
agents an option to maintain remission post-surgery. Future primary research is
needed in the medical induced remission setting which considers the length of
remission on enrolment and endoscopic or histological disease scores.
Additionally, secondary research to rank the various treatment options in the
post-surgical setting could be achieved through the use of network meta-analysis
and will guide policy makers in the future.