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10.1016/j.sbi.2017.02.002 http://scihub22266oqcxt.onion/10.1016/j.sbi.2017.02.002 C5420475!5420475!28363194     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Struct+Biol 2017 ; 43 (ä): 156-62 Nephropedia Template TP {{tp|p=28363194|t=2017. Small Molecule Modulation of Voltage Gated Sodium Channels |pdf=|usr=}}{{28363194}} gab.com Text Small Molecule Modulation of Voltage Gated Sodium Channels JO: Curr Opin Struct Biol http://www.kidney.de/pget.php?&tw=1&pmid=28363194 #FOAvip Voltage gated sodium channels are fundamental players in animals physiology. By triggering the depolarization of the lipid membrane they enable generation and propagation of the action potential. The involvement of these channels in numerous pathological conditions makes them relevant target for pharmaceutical intervention. Therefore, modulation of sodium conductance via small molecule binding constitutes a promising strategy to treat a large variety of diseases. However, this approach entails significant challenges: voltage gated sodium channels are complex nanomachines and the details of their workings have only recently started to become clear. Here we review ? with emphasis on the computational studies ? some of the major milestones in the long-standing search of a quantitative microscopic description of the molecular mechanism and modulation of voltage-gated sodium channels. Twit Text FOAVip Small Molecule Modulation of Voltage Gated Sodium Channels ????Curr Opin Struct Biol http://www.kidney.de/pget.php?&tw=1&pmid=28363194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28363194 #FOAvip English Wikipedia <ref>{{Cite pmid|28363194}}</ref> Small Molecule Modulation of Voltage Gated Sodium Channels #MMPMID28363194 Carnevale V; Klein ML Curr Opin Struct Biol 2017[Apr]; 43 (ä): 156-62 PMID28363194show ga Voltage gated sodium channels are fundamental players in animals physiology. By triggering the depolarization of the lipid membrane they enable generation and propagation of the action potential. The involvement of these channels in numerous pathological conditions makes them relevant target for pharmaceutical intervention. Therefore, modulation of sodium conductance via small molecule binding constitutes a promising strategy to treat a large variety of diseases. However, this approach entails significant challenges: voltage gated sodium channels are complex nanomachines and the details of their workings have only recently started to become clear. Here we review ? with emphasis on the computational studies ? some of the major milestones in the long-standing search of a quantitative microscopic description of the molecular mechanism and modulation of voltage-gated sodium channels. äSmall Molecule Modulation of Voltage Gated Sodium Channels (epmc).pdf DeepDyve Pubget Overpricing