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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Diabetol+Metab+Syndr
2017 ; 9
(ä): 31
Nephropedia Template TP
gab.com Text
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English Wikipedia
Urinary podocyte-associated mRNA levels correlate with proximal tubule
dysfunction in early diabetic nephropathy of type 2 diabetes mellitus
#MMPMID28484521
Petrica L
; Ursoniu S
; Gadalean F
; Vlad A
; Gluhovschi G
; Dumitrascu V
; Vlad D
; Gluhovschi C
; Velciov S
; Bob F
; Matusz P
; Milas O
; Secara A
; Simulescu A
; Popescu R
Diabetol Metab Syndr
2017[]; 9
(ä): 31
PMID28484521
show ga
AIM: The study assessed mRNA expression of podocyte-associated molecules in
urinary sediments of patients with type 2 diabetes mellitus (DM) in relation to
urinary podocytes, biomarkers of podocyte injury and of proximal tubule (PT)
dysfunction. METHODS: A total of 76 patients with type 2 DM and 20 healthy
subjects were enrolled in a cross-sectional study, and assessed concerning
urinary podocytes, urinary mRNA of podocyte-associated genes, urinary biomarkers
of podocyte damage and of PT dysfunction. RESULTS: We found significant
differences between urinary mRNA of podocyte-associated molecules in relation
with albuminuria stage. In multivariable regression analysis, urinary mRNA of
nephrin, podocin, alpha-actinin-4, CD2-associated protein, glomerular epithelial
protein 1 (GLEPP1), ADAM 10, and NF?B correlated directly with urinary podocytes,
albuminuria, urinary alpha(1)-microglobulin, urinary kidney-injury molecule-1,
nephrinuria, urinary vascular endothelial growth factor, urinary advanced
glycation end-products (AGE), and indirectly with eGFR (p < 0.0001, R(2) = 0.808;
p < 0.0001, R(2) = 0.825; p < 0.0001, R(2) = 0.805; p < 0.0001, R(2) = 0.663;
p < 0.0001, R(2) = 0.726; p < 0.0001, R(2) = 0.720; p < 0.0001, R(2) = 0.724).
CONCLUSIONS: In patients with type 2 DM there is an association between urinary
mRNA of podocyte-associated molecules, biomarkers of podocyte damage, and of PT
dysfunction. GLEPP1, ADAM10, and NF?B may be considered additional candidate
molecules indicative of early diabetic nephropathy. AGE could be involved in this
association.