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2017 ; 16
(1
): 88
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gab.com Text
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English Wikipedia
Low apolipoprotein M serum levels correlate with Systemic lupus erythematosus
disease activity and apolipoprotein M gene polymorphisms with Lupus
#MMPMID28476116
Du W
; Shen T
; Li H
; Liu Y
; He L
; Tan L
; Hu M
; Ren Y
Lipids Health Dis
2017[May]; 16
(1
): 88
PMID28476116
show ga
BACKGROUND: Sequence variation in gene promoters is often associated with disease
risk. In this study, we tested the hypothesis that common promoter variation in
the APOM gene is associated with systemic lupus erythematosus (SLE) risk and
SLE-related clinical phenotypes in a Chinese cohort. Meanwhile, we investigated
the expression of apolipoprotein M (APOM) in the serum of patients with systemic
lupus erythematosus (SLE) and its relationship with disease activity. METHODS: We
used a case-control design and genotyped 52 SLE patients and 52 healthy controls
for 19 APOM promoter single nucleotide polymorphism (SNP) (rs113947529,
rs1143030, rs114826514, rs116715239, rs12525463, rs1266078, rs2273612,
rs28432254, rs34490746, rs4947251, rs55880811, rs707921, rs74890500, rs75629491,
rs76611345, rs76794541, rs805264, rs805297, rs9267528). Genotyping was done by
matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS). The blood serum concentration of APOM was measured by an
enzyme-linked immunosorbent assay in SLE patients and controls. RESULTS: The
average concentration of APOM in serum was significantly lower in SLE patients
compared to controls and APOM levels in SLE patients with positive anti-dsDNA
antibodies were dramatically lower than that of patients with negative anti-dsDNA
antibodies (P = 0.011). It was interesting that APOM levels correlated with
systemic lupus erythematosus disease activity index (SLEDAI) scores (r = -0.396,
P = 0.004). No association between APOM and SLE susceptibility was detected in
our Han Chinese cohort. CONCLUSIONS: Our results demonstrated that lower APOM
levels in SLE patients and correlated with disease activity.
|Adolescent
[MESH]
|Adult
[MESH]
|Apolipoproteins M/*genetics
[MESH]
|Asian People
[MESH]
|Case-Control Studies
[MESH]
|Child
[MESH]
|Enzyme-Linked Immunosorbent Assay
[MESH]
|Female
[MESH]
|Genetic Predisposition to Disease/genetics
[MESH]