The Role of Necroptosis in Atherosclerotic Disease #MMPMID28480338
Leeper NJ
JACC Basic Transl Sci 2016[Oct]; 1 (6): 548-50 PMID28480338show ga
It is now known that cells do not always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in Science Advances, investigators reported that this proinflammatory process is active in human atherosclerosis, may promote growth of the necrotic core, and may serve as a novel molecular imaging and translational therapeutic target. These findings represent a major step in our goal to reduce coronary disease and stroke.