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10.1186/s12967-017-1198-4 http://scihub22266oqcxt.onion/10.1186/s12967-017-1198-4 C5418730!5418730 !28472963     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28472963 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Transl+Med 2017 ; 15 (1 ): 96 Nephropedia Template TP {{tp|p=28472963 |t=2017. Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency |pdf=|usr=}}{{28472963 }} gab.com Text Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28472963 #FOAvip BACKGROUND: Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogenous administration of low doses of IGF-1 can induce hepatoprotection in acute carbon tetrachloride (CCl(4))-induced liver damage compared to healthy controls (Wt Igf (+/+)). Additionally, the impact of IGF-1 deficiency on a damaged liver was investigated in mice with a partial deficit of this hormone (Hz Igf1 (+/-)). METHODS: Three groups of 25 ± 5-week-old healthy male mice (Wt Igf (+/+)) were included in the protocol: untreated controls (Wt). Controls that received CCl(4) (Wt + CCl(4)) and Wt + CCl(4) were treated subcutaneously with IGF-1 (2 µg/100 g body weight/day) for 10 days (Wt + CCl(4) + IGF1). In parallel, three IGF-1-deficient mice (Hz Igf1 (+/-)) groups were studied: untreated Hz, Hz + CCl(4), and Hz + CCl(4) + IGF-1. Microarray and real-time quantitative polymerase chain reaction (RT-qPCR) analyses, serum aminotransferases levels, liver histology, and malondialdehyde (MDA) levels were assessed at the end of the treatment in all groups. All data represent mean ± SEM. RESULTS: An altered gene coding expression pattern for proteins of the extracellular matrix, fibrosis, and cellular protection were found, as compared to healthy controls, in which IGF-1 therapy normalized in the series including healthy mice. Liver histology showed that Wt + CCl(4) + IGF1 mice had less oxidative damage, fibrosis, lymphocytic infiltrate, and cellular changes when compared to the Wt + CCl(4). Moreover, there was a correlation between MDA levels and the histological damage score (Pearson's r = 0.858). In the IGF-1-deficient mice series, similar findings were identified, denoting a much more vulnerable hepatic parenchyma. CONCLUSIONS: IGF1 treatment improved the biochemistry, histology, and genetic expression of pro-regenerative and cytoprotective factors in both series (healthy and IGF-1-deficient mice) with acute liver damage, suggesting that low doses of IGF-1, in acute liver damage, could be a feasible therapeutic option. Twit Text FOAVip Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28472963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28472963 #FOAvip English Wikipedia <ref>{{Cite pmid|28472963 }}</ref> Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency #MMPMID28472963 Morales-Garza LA ; Puche JE ; Aguirre GA ; Muñoz Ú ; García-Magariño M ; De la Garza RG ; Castilla-Cortazar I J Transl Med 2017[May]; 15 (1 ): 96 PMID28472963 show ga BACKGROUND: Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogenous administration of low doses of IGF-1 can induce hepatoprotection in acute carbon tetrachloride (CCl(4))-induced liver damage compared to healthy controls (Wt Igf (+/+)). Additionally, the impact of IGF-1 deficiency on a damaged liver was investigated in mice with a partial deficit of this hormone (Hz Igf1 (+/-)). METHODS: Three groups of 25 ± 5-week-old healthy male mice (Wt Igf (+/+)) were included in the protocol: untreated controls (Wt). Controls that received CCl(4) (Wt + CCl(4)) and Wt + CCl(4) were treated subcutaneously with IGF-1 (2 µg/100 g body weight/day) for 10 days (Wt + CCl(4) + IGF1). In parallel, three IGF-1-deficient mice (Hz Igf1 (+/-)) groups were studied: untreated Hz, Hz + CCl(4), and Hz + CCl(4) + IGF-1. Microarray and real-time quantitative polymerase chain reaction (RT-qPCR) analyses, serum aminotransferases levels, liver histology, and malondialdehyde (MDA) levels were assessed at the end of the treatment in all groups. All data represent mean ± SEM. RESULTS: An altered gene coding expression pattern for proteins of the extracellular matrix, fibrosis, and cellular protection were found, as compared to healthy controls, in which IGF-1 therapy normalized in the series including healthy mice. Liver histology showed that Wt + CCl(4) + IGF1 mice had less oxidative damage, fibrosis, lymphocytic infiltrate, and cellular changes when compared to the Wt + CCl(4). Moreover, there was a correlation between MDA levels and the histological damage score (Pearson's r = 0.858). In the IGF-1-deficient mice series, similar findings were identified, denoting a much more vulnerable hepatic parenchyma. CONCLUSIONS: IGF1 treatment improved the biochemistry, histology, and genetic expression of pro-regenerative and cytoprotective factors in both series (healthy and IGF-1-deficient mice) with acute liver damage, suggesting that low doses of IGF-1, in acute liver damage, could be a feasible therapeutic option. |Animals [MESH] |Body Weight [MESH] |Carbon Tetrachloride [MESH] |Cell Death [MESH] |Gene Expression Regulation [MESH] |Insulin-Like Growth Factor I/*deficiency/metabolism/*therapeutic use [MESH] |Lipid Peroxidation [MESH] |Liver Diseases/blood/genetics/*therapy [MESH] |Liver/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Organ Size [MESH] |RNA, Messenger/genetics/metabolism [MESH]Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver d(epmc).pdf DeepDyve Pubget Overpricing