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10.1182/blood-2016-12-758185 http://scihub22266oqcxt.onion/10.1182/blood-2016-12-758185 C5418638!5418638 !28202460     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28202460 &cmd=llinks): Failed to open stream: HTTP request failed! 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T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10 |pdf=|usr=}}{{28202460 }} gab.com Text T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10 JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=28202460 #FOAvip Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs) and CD11c(+) dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion. Twit Text FOAVip T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10 ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=28202460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28202460 #FOAvip English Wikipedia <ref>{{Cite pmid|28202460 }}</ref> T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10 #MMPMID28202460 Kapur R ; Kim M ; Aslam R ; McVey MJ ; Tabuchi A ; Luo A ; Liu J ; Li Y ; Shanmugabhavananthan S ; Speck ER ; Zufferey A ; Yousef G ; Zhang H ; Rondina MT ; Weyrich AS ; Porcelijn L ; Kuebler WM ; Slutsky AS ; Semple JW Blood 2017[May]; 129 (18 ): 2557-2569 PMID28202460 show ga Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs) and CD11c(+) dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion. |*Acute Lung Injury/etiology/immunology/prevention & control [MESH] |*Interleukin-10/immunology/pharmacology [MESH] |*Transfusion Reaction [MESH] |Animals [MESH] |Antibodies/immunology [MESH] |Dendritic Cells/*immunology/pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH]T regulatory cells and dendritic cells protect against transfusion-rel(epmc).pdf DeepDyve Pubget Overpricing