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10.1038/ncomms14811 http://scihub22266oqcxt.onion/10.1038/ncomms14811 C5418598!5418598!28466840     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28466840|t=2017. The comparative immunology of wild and laboratory mice, Mus musculus domesticus |pdf=|usr=}}{{28466840}} gab.com Text The comparative immunology of wild and laboratory mice, Mus musculus domesticus JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28466840 #FOAvip The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Twit Text FOAVip The comparative immunology of wild and laboratory mice, Mus musculus domesticus ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28466840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28466840 #FOAvip English Wikipedia <ref>{{Cite pmid|28466840}}</ref> The comparative immunology of wild and laboratory mice, Mus musculus domesticus #MMPMID28466840 Abolins S; King EC; Lazarou L; Weldon L; Hughes L; Drescher P; Raynes JG; Hafalla JCR; Viney ME; Riley EM Nat Commun 2017[]; 8 (ä): ä PMID28466840show ga The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. äThe comparative immunology of wild and laboratory mice, Mus musculus d(epmc).pdf DeepDyve Pubget Overpricing