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2017 ; 6
(4
): e136
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Transforming growth factor ?: a master regulator of the gut microbiota and immune
cell interactions
#MMPMID28523126
Bauché D
; Marie JC
Clin Transl Immunology
2017[Apr]; 6
(4
): e136
PMID28523126
show ga
The relationship between host organisms and their microbiota has co-evolved
towards an inter-dependent network of mutualistic interactions. This interplay is
particularly well studied in the gastrointestinal tract, where microbiota and
host immune cells can modulate each other directly, as well as indirectly,
through the production and release of chemical molecules and signals. In this
review, we define the functional impact of transforming growth factor-beta
(TGF-?) on this complex interplay, especially through its modulation of the
activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate
lymphoid cells (ILCs) and B cells.