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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 CEN+Case+Rep 2016 ; 5 (1): 87-90 Nephropedia Template TP
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Two autosomal dominant polycystic kidney (ADPKD) cases with advanced renal dysfunction, effectively treated with tolvaptan #MMPMID28509176
Kai H; Shinozaki Y; Nishikubo A; Watanabe M; Tawara T; Iwase M; Tsunoda R; Moriyama N; Usui T; Kawamura T; Nagai K; Hagiwara M; Saito C; Morito N; Usui J; Yamagata K
CEN Case Rep 2016[May]; 5 (1): 87-90 PMID28509176show ga
We report here two cases of autosomal dominant polycystic kidney disease (ADPKD) with renal dysfunction that were treated with tolvaptan. Case 1 was a 47-year-old man with a glomerular filtration rate (GFR) of 17.0 ml/min/1.73 m2 who received tolvaptan treatment (30 mg/day). After treatment, kidney pain was alleviated, and the estimated GFR (eGFR) decline improved from ?9.84 ml/min/1.73 m2 per year to ?4.08 ml/min/1.73 m2 per year, respectively. The rate of increase in total kidney volume was reduced from 18 % per year before treatment to 4 % per year following tolvaptan administration. Case 2 was a 44-year-old man with a GFR of 22.6 ml/min/1.73 m2, and the eGFR decline improved from ?5.76 ml/min/1.73 m2 per year before treatment to ?3.12 ml/min/1.73 m2 per year following tolvaptan treatment (30 mg/day). The rate of increase in total kidney volume was also decreased from 10 % per year before treatment to ?7 % per year following tolvaptan administration. These results suggested that tolvaptan may be effective in impeding kidney function aggravation and kidney volume increase in ADPKD patients with advanced renal dysfunction.