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10.1007/s12551-011-0046-7

http://scihub22266oqcxt.onion/10.1007/s12551-011-0046-7
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suck abstract from ncbi


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pmid28510003      Biophys+Rev 2011 ; 3 (2): 53-62
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  • SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation #MMPMID28510003
  • Wolfe JE; Ishiwata S; Braet F; Whan R; Su Y; Lal S; dos Remedios CG
  • Biophys Rev 2011[Jun]; 3 (2): 53-62 PMID28510003show ga
  • Striated muscle is well known to exist in either of two states?contraction or relaxation?under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under conditions of partial activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is characterised by auto-oscillation between rapid-lengthening and slow-shortening phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the result of fluctuating Ca2+ levels, but is rather an intrinsic and fundamental phenomenon of the actomyosin motor. Summarised in this review are the experimental data on SPOC and its fundamental mechanism. SPOC presents a novel technique for studying independent communication and coordination between sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may represent a new way of demonstrating functional defects of sarcomeres in human heart failure.
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