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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biophys+Rev
2011 ; 3
(2
): 53-62
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SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in
striated muscle at partial activation
#MMPMID28510003
Wolfe JE
; Ishiwata S
; Braet F
; Whan R
; Su Y
; Lal S
; Dos Remedios CG
Biophys Rev
2011[Jun]; 3
(2
): 53-62
PMID28510003
show ga
Striated muscle is well known to exist in either of two states-contraction or
relaxation-under the regulation of Ca(2+) concentration. Described here is a less
well-known third, intermediate state induced under conditions of partial
activation, known as SPOC (SPontaneous Oscillatory Contraction). This state is
characterised by auto-oscillation between rapid-lengthening and slow-shortening
phases. Notably, SPOC occurs in skinned muscle fibres and is therefore not the
result of fluctuating Ca(2+) levels, but is rather an intrinsic and fundamental
phenomenon of the actomyosin motor. Summarised in this review are the
experimental data on SPOC and its fundamental mechanism. SPOC presents a novel
technique for studying independent communication and coordination between
sarcomeres. In cardiac muscle, this auto-oscillatory property may work in concert
with electro-chemical signalling to coordinate the heartbeat. Further, SPOC may
represent a new way of demonstrating functional defects of sarcomeres in human
heart failure.