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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Trop+Med+Hyg
2017 ; 96
(5
): 1117-1123
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A New Handheld Device for the Detection of Falsified Medicines: Demonstration on
Falsified Artemisinin-Based Therapies from the Field
#MMPMID28219992
Wilson BK
; Kaur H
; Allan EL
; Lozama A
; Bell D
Am J Trop Med Hyg
2017[May]; 96
(5
): 1117-1123
PMID28219992
show ga
AbstractPoor-quality medicines are a major problem for health-care systems in
resource-poor settings as identifying falsified medicines requires a complex
laboratory infrastructure such as a Medicines Quality Control Laboratory. We
report here an evaluation of a low-cost, handheld near-infrared spectrometer
(NIRS) device by analyzing a library of artemisinin-based combination therapy
(ACT) medicines to determine its usefulness as a drug-screening tool. The "SCiO"
research prototype device was used to collect NIR spectra of a library of ACT and
artesunate monotherapy medicine samples previously collected in Bioko Island and
Equatorial Guinea and Kintampo, Ghana. The quality of these samples had been
categorized as falsified, substandard, and quality assured based on the amount of
stated active pharmaceutical ingredients detected using high-performance liquid
chromatography photodiode array. Numerical analyses were performed on the NIR
spectra to assess the usefulness of NIR to identify falsified and substandard
medicines. The NIRS device was successful at detecting falsified medicines in all
cases where the library contained both quality assured and falsified medicines of
the same stated brand of medicines. The NIRS device was successful at identifying
substandard amounts of artesunate but not amodiaquine in the ACT samples (N = 15)
of artesunate-amodiaquine. This work reveals that this low-cost, portable NIRS
device is promising for screening ACTs for falsified samples and could enable
widespread drug screening at all points of the health system.
free
free
free
