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10.1093/nar/gkx126 http://scihub22266oqcxt.onion/10.1093/nar/gkx126 C5416901!5416901!28334891     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (8): 4590-605 Nephropedia Template TP {{tp|p=28334891|t=2017. RAD51 interconnects between DNA replication, DNA repair and immunity |pdf=|usr=}}{{28334891}} gab.com Text RAD51 interconnects between DNA replication, DNA repair and immunity JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28334891 #FOAvip RAD51, a multifunctional protein, plays a central role in DNA replication and homologous recombination repair, and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm, triggering a STING-mediated innate immune response after replication stress and DNA damage. In the absence of RAD51, the unprotected newly replicated genome is degraded by the exonuclease activity of MRE11, and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing, RAD51 is also implicated in the suppression of innate immunity. Thus, our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling, placing it at the hub of new interconnections between DNA replication, DNA repair, and immunity. Twit Text FOAVip RAD51 interconnects between DNA replication, DNA repair and immunity ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28334891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28334891 #FOAvip English Wikipedia <ref>{{Cite pmid|28334891}}</ref> RAD51 interconnects between DNA replication, DNA repair and immunity #MMPMID28334891 Bhattacharya S; Srinivasan K; Abdisalaam S; Su F; Raj P; Dozmorov I; Mishra R; Wakeland EK; Ghose S; Mukherjee S; Asaithamby A Nucleic Acids Res 2017[May]; 45 (8): 4590-605 PMID28334891show ga RAD51, a multifunctional protein, plays a central role in DNA replication and homologous recombination repair, and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm, triggering a STING-mediated innate immune response after replication stress and DNA damage. In the absence of RAD51, the unprotected newly replicated genome is degraded by the exonuclease activity of MRE11, and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing, RAD51 is also implicated in the suppression of innate immunity. Thus, our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling, placing it at the hub of new interconnections between DNA replication, DNA repair, and immunity. äRAD51 interconnects between DNA replication, DNA repair and immunity (epmc).pdf DeepDyve Pubget Overpricing