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2017 ; 7
(4
): e1102
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A missense polymorphism in the putative pheromone receptor gene VN1R1 is
associated with sociosexual behavior
#MMPMID28440809
Henningsson S
; Hovey D
; Vass K
; Walum H
; Sandnabba K
; Santtila P
; Jern P
; Westberg L
Transl Psychiatry
2017[Apr]; 7
(4
): e1102
PMID28440809
show ga
Pheromones regulate social and reproductive behavior in most mammalian species.
These effects are mediated by the vomeronasal and main olfactory systems. Effects
of putative pheromones on human neuroendocrine activity, brain activity and
attractiveness ratings suggest that humans may communicate via similar
chemosignaling. Here we studied two samples of younger and older individuals,
respectively, with respect to one nonsynonymous polymorphism in the gene encoding
the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous
polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in
both samples had self-reported their sociosexual behavior using the sociosexual
orientation inventory, including questions regarding lifetime number of one-night
stands, number of partners last year and expected number of partners the coming 5
years. In women, there was a significant association between the VN1R1
polymorphism and sociosexual behavior in both samples, driven specifically by the
question regarding one-night stands. Our results support the hypothesis that
human social interaction is modulated by communication via chemosignaling.