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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Adv+Pharm+Technol+Res
2017 ; 8
(2
): 63-66
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Comparison of amoxicillin and metronidazole effect on three-drug regimen for the
treatment of Helicobacter pylori infection in children
#MMPMID28516058
Kasiri KA
; Khoshdel A
; Karimi A
; Sedehi M
; Kasiri N
J Adv Pharm Technol Res
2017[Apr]; 8
(2
): 63-66
PMID28516058
show ga
Helicobacter pylori is an important risk factor for chronic gastritis, peptic
ulcer, and gastric cancer. Three-drug regimen is the first-line treatment for
this infection, but the response rate to treatment varies in different
geographical regions. This study was conducted to comparatively determine the
effect of amoxicillin and metronidazole on three-drug regimen to treat H. pylori
infection in 1-15-year-old children. This clinical trial was conducted on 82
patients aged 1-15 years with convenience sampling referring to the Endoscopy
Unit of Hajar Hospital, Shahrekord. Group 1 was administered with clarithromycin,
amoxicillin, and omeprazole (CAO), and Group 2 with, clarithromycin,
metronidazole, and omeprazole (CMO). One month after completion of the treatment,
stool antigen test was used to study the eradication of H. pylori. Data were
analyzed using SPSS software by Chi-square test. Three of the 82 patients were
excluded from the study because of side effects caused by drugs. Nearly 87.2% of
the patients in CAO-treated group and 92.5% in CMO-treated group had response to
treatment. There was no significant difference in eradication rate between the
two regimens (P = 0.43). The two regimens displayed no superiority over each
other for eradicating H. pylori infection and response rate to treatment in
children aged 1-15 years.