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2017 ; 3
(ä): 17020
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gab.com Text
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English Wikipedia
Incomplete paraplegia caused by extramedullary hematopoiesis in a patient with
thalassemia intermedia
#MMPMID28503326
Hisamud-Din N
; Mustafah NM
; Fauzi AA
; Hashim NM
Spinal Cord Ser Cases
2017[]; 3
(ä): 17020
PMID28503326
show ga
INTRODUCTION: Extramedullary hematopoiesis (EMH) is the production of blood cell
precursors outside the bone marrow that occur in various hematological diseases.
In patients with thalassemia intermedia, ineffective erythropoiesis drives
compensatory EMH in the liver, pancreas, pleura, spleen, ribs and spine. CASE
PRESENTATION: We describe a patient with thalassemia intermedia who presented
with acute neurological symptoms caused by paraspinal EMH, which responded well
to combination therapy of steroid, hypertransfusion, laminectomy and excision of
pseudotumor and hydroxyurea therapy to boost the formation of fetal haemoglobin.
DISCUSSION: Prompt recognition of EMH based on clinical presentation and typical
radiological findings should be made. Early treatment is recommended to prevent
irreversible damage to the spinal cord.