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10.1186/s11658-016-0021-1 http://scihub22266oqcxt.onion/10.1186/s11658-016-0021-1 C5415738!5415738!28536621     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Biol+Lett 2016 ; 21 (ä): ä Nephropedia Template TP {{tp|p=28536621|t=2016. Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair |pdf=|usr=}}{{28536621}} gab.com Text Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair JO: Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28536621 #FOAvip Background: The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury. Methods: NRK-52E cells with overexpressed or silenced RGC-32 were constructed via transient transfection with RGC-32 expression plasmid and RGC-32 siRNA plasmid, and the cell cycle distribution was determined. The expression levels of fibrosis factors, including smooth muscle action (?-SMA), fibronectin (FN) and E-cadherin, were assessed in cells with silenced RGC-32. Results: The cells were injured via TNF-? treatment, and the injury was detectable by the enhanced expression of neutrophil gelatinase-associated lipocalin (NGAL). RGC-32 expression also increased significantly. The number of cells at G2/M phase increased dramatically in RGC-32 silenced cells, indicating that RGC-32 silencing induced G2/M arrest. In addition, after treatment with TNF-?, the NRK-52E cells with silenced RGC-32 showed significantly increased expression of ?-SMA and FN, but decreased expression of E-cadherin. Conclusions: The results of this study suggest that RGC-32 probably has an important impact on the repair process of renal tubular epithelial cells in vitro by regulating the G2/M phase checkpoint, cell fibrosis and cell adhesion. However, the exact mechanism needs to be further elucidated. Twit Text FOAVip Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair ????Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28536621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28536621 #FOAvip English Wikipedia <ref>{{Cite pmid|28536621}}</ref> Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair #MMPMID28536621 Shen Yl; Liu Hj; Sun L; Niu Xl; Kuang Xy; Wang P; Hao S; Huang Wy Cell Mol Biol Lett 2016[]; 21 (ä): ä PMID28536621show ga Background: The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury. Methods: NRK-52E cells with overexpressed or silenced RGC-32 were constructed via transient transfection with RGC-32 expression plasmid and RGC-32 siRNA plasmid, and the cell cycle distribution was determined. The expression levels of fibrosis factors, including smooth muscle action (?-SMA), fibronectin (FN) and E-cadherin, were assessed in cells with silenced RGC-32. Results: The cells were injured via TNF-? treatment, and the injury was detectable by the enhanced expression of neutrophil gelatinase-associated lipocalin (NGAL). RGC-32 expression also increased significantly. The number of cells at G2/M phase increased dramatically in RGC-32 silenced cells, indicating that RGC-32 silencing induced G2/M arrest. In addition, after treatment with TNF-?, the NRK-52E cells with silenced RGC-32 showed significantly increased expression of ?-SMA and FN, but decreased expression of E-cadherin. Conclusions: The results of this study suggest that RGC-32 probably has an important impact on the repair process of renal tubular epithelial cells in vitro by regulating the G2/M phase checkpoint, cell fibrosis and cell adhesion. However, the exact mechanism needs to be further elucidated. äResponse gene to complement 32 regulates the G2/M phase checkpoint dur(epmc).pdf DeepDyve Pubget Overpricing