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10.1016/j.immuni.2017.02.019 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.02.019 C5415308!5415308!28329707     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2017 ; 46 (3): 504-15 Nephropedia Template TP {{tp|p=28329707|t=2017. Dendritic cells display subset and tissue-specific maturation dynamics over human life |pdf=|usr=}}{{28329707}} gab.com Text Dendritic cells display subset and tissue-specific maturation dynamics over human life JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28329707 #FOAvip Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology, but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals aged <1?93years. The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-?+CD1c+) subsets was a function of tissue site and conserved between donors. We identified cDC2 as the major mature (HLA-DRhi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa. Twit Text FOAVip Dendritic cells display subset and tissue-specific maturation dynamics over human life ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=28329707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28329707 #FOAvip English Wikipedia <ref>{{Cite pmid|28329707}}</ref> Dendritic cells display subset and tissue-specific maturation dynamics over human life #MMPMID28329707 Granot T; Senda T; Carpenter DJ; Matsuoka N; Weiner J; Gordon CL; Miron M; Kumar B; Griesemer A; Ho SH; Lerner H; Thome JJ; Connors T; Reizis B; Farber DL Immunity 2017[Mar]; 46 (3): 504-15 PMID28329707show ga Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology, but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals aged <1?93years. The distribution of cDC1 (CD141hiCD13hi) and cDC2 (Sirp-?+CD1c+) subsets was a function of tissue site and conserved between donors. We identified cDC2 as the major mature (HLA-DRhi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa. äDendritic cells display subset and tissue-specific maturation dynamics(epmc).pdf DeepDyve Pubget Overpricing