Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28507728
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Therapeutic plasmapheresis for hypertriglyceridemia-associated acute
pancreatitis: case series and review of the literature
#MMPMID28507728
Joglekar K
; Brannick B
; Kadaria D
; Sodhi A
Ther Adv Endocrinol Metab
2017[Apr]; 8
(4
): 59-65
PMID28507728
show ga
BACKGROUND: Severe hypertriglyceridemia (HTG) is the third leading cause of acute
pancreatitis (AP) in the United States. The current standard of care includes
management of HTG using pharmacological therapy. More recently, plasmapheresis
has been proposed as a therapeutic tool for decreasing triglyceride (TG) levels,
especially in critically ill patients. Few studies are available to ascertain
overall benefits of plasmapheresis over traditional management. OBJECTIVE: To
analyze the outcomes of patients treated with plasmapheresis for severe
HTG-associated pancreatitis. METHODS: We conducted a retrospective chart review
of three patients with severe HTG- associated (TGs greater than 1000 mg/dl; 11.29
mmol/l) AP at the Methodist University Hospital. All the patients underwent
plasmapheresis as part of their treatment. RESULTS: The average TG level before
plasmapheresis was 3532 mg/dl (range: 2524-4562 mg/dl; 39.9 mmol/l; range:
28.5-51.6 mmol/l). All patients made a full recovery, with a significant
improvement in TG levels after plasmapheresis. The mean number of sessions was
1.3 (range 1-2), and mean TG level after plasmapheresis was 1051 mg/dl (range:
509-1771 mg/dl; 11.9 mmol/l; range: 5.8-20 mmol/l). After the first session, the
average reduction of TG level was 2481 mg/dl (range 753-3750 mg/dl; 28 mmol/l;
range: 8.5-42.4 mmol/l) or approximately 70%. None of the patients developed
complications related to plasmapheresis. CONCLUSIONS: Plasmapheresis can be an
effective and rapid treatment option in patients with severe HTG and
complications. However, further research, including randomized controlled
studies, is necessary.
free
free
free
